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一种新的二酮哌嗪，环-(4-S-羟基-R-脯氨酸-R-异亮氨酸），来自澳大利亚海绵Stelletta sp.的标本。

A new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp.

机构信息

Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville 4810, Australia.

Defence Science & Technology Organisation, 506 Lorimer St. Fishermans Bend, Victoria 3207, Australia.

出版信息

Mar Drugs. 2011;9(11):2469-2478. doi: 10.3390/md9112469. Epub 2011 Nov 22.

DOI:10.3390/md9112469
PMID:22163196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3229245/
Abstract

While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6), C(4) (7) and C(6) (8). The isolation and structure elucidation of the diketopiperazine (1), together with the activity of 1-8 against a panel of human and mammalian cell lines are discussed.

摘要

在研究澳大利亚海洋海绵 Stelletta sp.（寻常海绵纲）甲醇提取物的细胞毒性活性时，分离得到了一种新的二酮哌嗪，环己基-(4-S-羟基-R-脯氨酸-R-异亮氨酸)（1），同时还分离得到了已知的苯并酰胺；A（2）、F（3）、N（4）、Y（5）和苯并唑；Z（6）、C(4)（7）和 C(6)（8）。讨论了二酮哌嗪（1）的分离和结构阐明，以及 1-8 对一系列人类和哺乳动物细胞系的活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/284e/3229245/3b41b56c38d9/marinedrugs-09-02469f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/284e/3229245/c4db6f0e031b/marinedrugs-09-02469f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/284e/3229245/3b41b56c38d9/marinedrugs-09-02469f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/284e/3229245/c4db6f0e031b/marinedrugs-09-02469f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/284e/3229245/3b41b56c38d9/marinedrugs-09-02469f2.jpg

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