来自海洋海绵Stelletta sp.的新型溶血磷脂酰胆碱和甘油单酯

New lysophosphatidylcholines and monoglycerides from the marine sponge Stelletta sp.

作者信息

Zhao Qingchun, Mansoor Tayyab A, Hong Jongki, Lee Chong-O, Im Kwang Sik, Lee Dong Seok, Jung Jee H

机构信息

College of Pharmacy, Pusan National University, Busan 609-735, Korea.

出版信息

J Nat Prod. 2003 May;66(5):725-8. doi: 10.1021/np0300075.

DOI:10.1021/np0300075

PMID:12762820

Abstract

Two new lysophosphatidylcholines (1, 2) and four new monoglycerides (5-8) were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures of the new compounds were established on the basis of NMR and MS analyses. The stereochemistry was defined by comparison of the optical rotation. The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines.

摘要

通过生物活性导向分离，从海洋海绵Stelletta sp.中分离出两种新的溶血磷脂酰胆碱（1, 2）和四种新的甘油单酯（5 - 8）。基于核磁共振（NMR）和质谱（MS）分析确定了新化合物的平面结构。通过比较旋光度确定了立体化学。对这些化合物针对一小批五种人类肿瘤细胞系进行了细胞毒性评估。