Persson S, Danielsson D, Kjellander J, Wallensten S
Acta Chir Scand. 1976;142(1):84-90.
Patients with terminal ileitis or regional enterocolitis have been examined for signs of infection due to Yersinia enterocolitica serotype 3. The patients were grouped according to the length of preoperative history. Among 18 patients with preoperative symptoms of one week or less there were nine with positive signs of Yersinia enterocolitica infection. None of these patients developed the chronic form of Crohn's disease while two of the primarily Yersinia negative patients progressed to the chronic form. Among nine patients with preoperative symptoms of one week to three months there was one patient with positive signs of Yersinia enterocolitica infection. This patient has remained healthy whereas seven of the negative ones progressed to the chronic form of Crohn's disease. None of the patients with established Crohn's disease of the chronic form had signs of recent Yersinia infection. The findings indicate that patients with acute terminal ileitis and positive signs of Yersinia infection are not likely to progress to the chronic form of Crohn's disease. Bacteriologic and serologic investigation for Yersinia infection are therefore of prognostic value.
对患有末端回肠炎或局限性小肠结肠炎的患者进行了检查，以查找因小肠结肠炎耶尔森菌3型感染的迹象。患者根据术前病史的长短进行分组。在术前症状持续一周或更短时间的18例患者中，有9例小肠结肠炎耶尔森菌感染呈阳性体征。这些患者均未发展为克罗恩病的慢性形式，而最初小肠结肠炎耶尔森菌检测呈阴性的患者中有2例进展为慢性形式。在术前症状持续一周至三个月的9例患者中，有1例小肠结肠炎耶尔森菌感染呈阳性体征。该患者一直保持健康，而7例检测呈阴性的患者进展为克罗恩病的慢性形式。已确诊为慢性形式克罗恩病的患者均无近期小肠结肠炎耶尔森菌感染的迹象。这些发现表明，患有急性末端回肠炎且小肠结肠炎耶尔森菌感染呈阳性体征的患者不太可能进展为克罗恩病的慢性形式。因此，对小肠结肠炎耶尔森菌感染进行细菌学和血清学调查具有预后价值。
