Quitkin F, Rifkin A, Gochfeld L, Klein D F
Am J Psychiatry. 1977 Jan;134(1):84-7. doi: 10.1176/ajp.134.1.84.
Although tardive dyskinesia, a serious and sometimes irreversible side effect of antipsychotic drug use, is becoming increasingly common, there is still considerable confusion concerning the course of the syndrome. The authors observed 12 psychiatric patients with tardive dyskinesia from the inception of the syndrome. They found that first symptoms rarely persisted if antipsychotics were discontinued and concluded that the length of time symptoms have persisted prior to drug discontinuation, not age at onset, may be the major variable determining reversibility of the syndrome.
迟发性运动障碍是使用抗精神病药物产生的一种严重且有时不可逆的副作用，虽然它正变得越来越普遍，但对于该综合征的病程仍存在相当多的困惑。作者从综合征开始就观察了12例患有迟发性运动障碍的精神病患者。他们发现，如果停用抗精神病药物，最初症状很少持续存在，并得出结论，在停药前症状持续的时间，而非发病年龄，可能是决定该综合征可逆性的主要变量。
