Pineda D A, Puerta I C, Merchán V, Arango C P, Galvis A Y, Velásquez B, Gómez M, Builes A, Zapata M, Montoya P, Martínez J, Salazar E O, Lopera F
Universidad de San Buenaventura. Facultad de Psicologia, Medellin, Antioquia, Colombia.
Rev Neurol. 2003;36(7):609-13.
Some perinatal factors have been associated with attention d ficit/hyperactivity disorder (ADHD).
To estimate the association between perinatal factor and ADHD diagnosis in school, aged 6 to 11 years, children from Medell n city (Colombia).
A randomized sample of 200 cases, 6 to 11 year old, with standardized ADHD diagnosis was selected. A randomized sample of 200 control children, 6 to 11 year old, was selected from a data base of 70 schools of Medell n city. The same diagnostic protocol was administered to controls. A questionnaire with questions about pregnancy, delivery an neonatal period was given to the mothers. Data were analyzed using cross tabulation and stepwise logistic multiple regression analyses.
Miscarriage symptoms, premature delivery symptoms, severe flu attacks (cold with fever, without virus confirmation), tobacco abuse, alcohol abuse (to become drunk), minor congenital malformations, neonatal seizures and hospitalizations during newborn period were factors associated with ADHD diagnosis (p< 0.05). However, stepwise logistic multiple regression analysis selected a block of variables formed by premature delivery symptoms, severe flu attacks and neonatal seizures as significant perinatal risk factors (p< 0.01) for ADHD diagnosis.
一些围产期因素与注意力缺陷/多动障碍（ADHD）有关。
评估哥伦比亚麦德林市6至11岁在校儿童围产期因素与ADHD诊断之间的关联。
选取200例6至11岁经标准化ADHD诊断的病例作为随机样本。从麦德林市70所学校的数据库中选取200名6至11岁对照儿童作为随机样本。对对照组采用相同的诊断方案。向母亲们发放一份关于怀孕、分娩和新生儿期的问卷。使用交叉列表和逐步逻辑多元回归分析对数据进行分析。
流产症状、早产症状、严重流感发作（伴有发热的感冒，未确诊病毒感染）、烟草滥用、酒精滥用（致醉）、轻微先天性畸形、新生儿惊厥以及新生儿期住院是与ADHD诊断相关的因素（p<0.05）。然而，逐步逻辑多元回归分析选择由早产症状、严重流感发作和新生儿惊厥组成的一组变量作为ADHD诊断的显著围产期危险因素（p<0.01）。
