Kajander E Olavi, Ciftcioglu Neva, Aho Katja, Garcia-Cuerpo Enrique
Department of Biochemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland.
Urol Res. 2003 Jun;31(2):47-54. doi: 10.1007/s00240-003-0304-7. Epub 2003 Mar 27.
Kidney stone formation is a multifactorial disease in which the defence mechanisms and risk factors are imbalanced in favour of stone formation. We have proposed a novel infectious agent, mineral forming nanobacteria (NB), to be active nidi that attach to, invade and damage the urinary epithelium of collecting ducts and papilla forming the calcium phosphate center(s) found in most kidney stones. Stone formation may proceed in urine supersaturated with calcium phosphate, calcium oxalate and uric acid/urate under the influence of crystallization promoters and inhibitors. Our hypothesis underlines the role of active nidi: even supersaturated urine requires nidi for crystallization to appear.
肾结石形成是一种多因素疾病，其中防御机制和风险因素失衡，有利于结石形成。我们提出了一种新型感染因子，即成矿物质纳米细菌（NB），它是活跃的病灶，可附着、侵入并损伤集合管和乳头的尿路上皮，形成大多数肾结石中发现的磷酸钙中心。在结晶促进剂和抑制剂的影响下，结石形成可能在磷酸钙、草酸钙和尿酸/尿酸盐过饱和的尿液中进行。我们的假设强调了活跃病灶的作用：即使是过饱和尿液也需要病灶才能出现结晶。
