Valle Rosaura P C, Jendoubi Moncef
Milagen Inc, 770 South 13th Street, Richmond, CA 94804, USA.
Curr Opin Drug Discov Devel. 2003 Mar;6(2):197-203.
Antibodies have proven to be exquisite investigation tools in the field of life sciences. They also constitute one of the oldest and most successful biological products for diagnostics and therapeutics. This review investigates the current use of antibodies in target discovery. To address this topic in a larger context, established and emerging technologies that are expected to contribute to target discovery will first be examined. These technologies include: mass spectroscopic analysis of proteins, protein-protein interaction and other network analysis approaches, as well as protein and antibody arrays. The potential of antibody engineering and the ANTIBIOMIX technology will then be discussed; antibody therapeutics, however, will not be examined.
抗体已被证明是生命科学领域中极为出色的研究工具。它们也是用于诊断和治疗的最古老且最成功的生物制品之一。本综述探讨了抗体在靶点发现中的当前应用。为了在更广泛的背景下探讨这个话题，首先将研究有望对靶点发现做出贡献的现有技术和新兴技术。这些技术包括：蛋白质的质谱分析、蛋白质-蛋白质相互作用及其他网络分析方法，以及蛋白质和抗体阵列。随后将讨论抗体工程和ANTIBIOMIX技术的潜力；然而，抗体治疗将不在本文探讨范围内。
