Khachatourians Armond G, Patzakis Michael J, Roidis Nikolaos, Holtom Paul D
Keck School of Medicine, University of Southern California, LAC+USC Medical Center, Department of Orthopaedic Surgery, Los Angeles, CA 90033, USA.
Clin Orthop Relat Res. 2003 Apr(409):186-94. doi: 10.1097/01.blo.0000057991.41099.47.
The purpose of the current study was to determine the usefulness of erythrocyte sedimentation rate and C-reactive protein in pediatric bone and joint infections treated with and without surgery. The medical records of 50 patients admitted for acute osteomyelitis, septic arthritis, or both were reviewed retrospectively. There were 22 patients with septic arthritis, 20 with osteomyelitis, and eight with osteomyelitis with adjacent septic arthritis. There were 25 patients each in the surgical and nonsurgical groups. There was a statistically significant difference between the two groups regarding mean days to peak and normalization of erythrocyte sedimentation rate values and normalization of C-reactive protein values. Statistically significant differences were revealed for the mean days to normalization of erythrocyte sedimentation rate and C-reactive protein values among the patients with a diagnosis of osteomyelitis, septic arthritis, or both. The mean days to peak and normalization for erythrocyte sedimentation rate and C-reactive protein were twice as long in the surgical group as compared with the nonsurgical group. Complete recovery was achieved by all patients. This information should help the clinician in the diagnosis and treatment of children having surgery for acute osteomyelitis and septic arthritis.
本研究的目的是确定红细胞沉降率和C反应蛋白在接受或未接受手术治疗的小儿骨与关节感染中的作用。回顾性分析了50例因急性骨髓炎、化脓性关节炎或两者均有而入院的患者的病历。其中有22例化脓性关节炎患者，20例骨髓炎患者，8例伴有相邻化脓性关节炎的骨髓炎患者。手术组和非手术组各有25例患者。两组在红细胞沉降率峰值天数、红细胞沉降率值恢复正常天数以及C反应蛋白值恢复正常天数方面存在统计学显著差异。在诊断为骨髓炎、化脓性关节炎或两者均有的患者中，红细胞沉降率和C反应蛋白恢复正常的平均天数存在统计学显著差异。手术组红细胞沉降率和C反应蛋白达到峰值及恢复正常的平均天数是非手术组的两倍。所有患者均实现了完全康复。这些信息应有助于临床医生对因急性骨髓炎和化脓性关节炎接受手术的儿童进行诊断和治疗。
