Morikawa K, Nonaka M, Torii Ikuko, Morikawa S
Department of Nutrition, Division of Clinical Nutrition, Sagami Women's University, 2-1-1 Bunkyo, Sagamihara, Kanagawa 228-8533, Japan.
Int J Antimicrob Agents. 2003 Apr;21(4):334-9. doi: 10.1016/s0924-8579(02)00358-8.
We examined the effect of fosfomycin (FOM) on the inflammatory response induced by carrageenan in the rat. Air pouches were induced subcutaneously on the backs of rats and injected with carrageenan. The rats were treated with either vehicle or FOM at a dose of 100 mg/kg 1 h before carrageenan challenge. After carrageenan challenge (48 h), the air pouches were removed and analyzed. The volume, protein amounts and cell counts in the exudate obtained from FOM-treated animals were significantly reduced compared with that from vehicle-treated animals. The contents of PGE(2) and TNF-alpha, and mRNA for cyclooxygenase-2 were also markedly suppressed in FOM-treated rats. Histological examination showed suppression of the inflammatory response in the pouch tissues from FOM-treated rats.
我们研究了磷霉素（FOM）对角叉菜胶诱导的大鼠炎症反应的影响。在大鼠背部皮下诱导气袋，并注射角叉菜胶。在角叉菜胶激发前1小时，大鼠分别接受载体或剂量为100 mg/kg的FOM治疗。角叉菜胶激发后（48小时），取出气袋并进行分析。与接受载体治疗的动物相比，接受FOM治疗的动物渗出液的体积、蛋白量和细胞计数显著降低。FOM治疗的大鼠中前列腺素E2（PGE2）和肿瘤坏死因子-α（TNF-α）的含量以及环氧化酶-2的mRNA也明显受到抑制。组织学检查显示，FOM治疗的大鼠气袋组织中的炎症反应受到抑制。
