Baylin Ana, Kabagambe Edmond K, Ascherio Alberto, Spiegelman Donna, Campos Hannia
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
J Nutr. 2003 Apr;133(4):1186-91. doi: 10.1093/jn/133.4.1186.
Trans-fatty acid intake is associated with coronary heart disease (CHD), but the atherogenic potential of individual trans-fatty acids (FA) from partially hydrogenated oils (18:1 and 18:2) or meat and dairy products (16:1 and 18:1) is unclear. Incident cases (n = 482) of a first nonfatal myocardial infarction (MI) were matched with population controls (n = 482) for age, gender and area of residence, all living in Costa Rica. Trans-FA in adipose tissue samples were assessed by gas chromatography. Odds ratios (OR) and 95% confidence intervals were calculated from conditional logistic regression models. Total adipose tissue trans-fat was positively associated with risk of MI. After adjusting for established risk factors and other confounders, the OR by quintiles of total trans-fat were 1.00, 1.34, 2.05, 2.22 and 2.94 (P-test for trend < 0.01). This association was attributed mainly to 18:2 trans-FA that were abundant in both adipose tissue and in partially hydrogenated soybean oil, margarines and baked products used by this population; OR = 1.00, 0.96, 2.09, 3.51 and 5.05 (P-test for trend < 0.001). Adipose tissue 16:1 trans-FA were also associated with MI; OR = 1.00, 1.57, 1.39, 1.34 and 2.58 (P-test for trend < 0.05). An association with 18:1 trans-FA was not detected. High 18:2 trans-FA in adipose tissue are associated with increased risk of MI. Because the use of hydrogenated oils is increasing worldwide, consumers should be aware of the harmful effects of products containing partially hydrogenated oils.
反式脂肪酸的摄入与冠心病（CHD）相关，但来自部分氢化油（18:1和18:2）或肉类及奶制品（16:1和18:1）的个别反式脂肪酸（FA）的致动脉粥样化潜力尚不清楚。首次非致命性心肌梗死（MI）的发病病例（n = 482）与年龄、性别和居住地区相匹配的人群对照（n = 482）进行比较，所有研究对象均居住在哥斯达黎加。通过气相色谱法评估脂肪组织样本中的反式脂肪酸。从条件逻辑回归模型计算比值比（OR）和95%置信区间。总脂肪组织反式脂肪与心肌梗死风险呈正相关。在对既定风险因素和其他混杂因素进行调整后，总反式脂肪五分位数的OR分别为1.00、1.34、2.05、2.22和2.94（趋势P检验<0.01）。这种关联主要归因于在脂肪组织以及该人群使用的部分氢化大豆油、人造黄油和烘焙产品中含量丰富的18:2反式脂肪酸；OR分别为1.00、0.96、2.09、3.51和5.05（趋势P检验<0.001）。脂肪组织中的16:1反式脂肪酸也与心肌梗死相关；OR分别为1.00、1.57、1.39、1.34和2.58（趋势P检验<0.05）。未检测到与18:1反式脂肪酸的关联。脂肪组织中高含量的18:2反式脂肪酸与心肌梗死风险增加相关。由于氢化油在全球的使用正在增加，消费者应意识到含部分氢化油产品的有害影响。
