来自大戟的三种新的英戈尔二萜：细胞毒性活性评估
Three new ingol diterpenes from Euphorbia nivulia: evaluation of cytotoxic activity.
作者信息
Ravikanth Veluri, Lakshmi Niranjan Reddy Vanimireddy, Vijender Reddy Adelli, Ravinder Kodela, Prabhakar Rao Tadikamalla, Siva Ram Tejomoorty, Anand Kumar Kondapi, Prakesh Vamanarao Diwan, Venkateswarlu Yenamandra
机构信息
Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
出版信息
Chem Pharm Bull (Tokyo). 2003 Apr;51(4):431-4. doi: 10.1248/cpb.51.431.
The latex of Euphorbia nivulia afforded three new ingol diterpenes, 3-acetyl-8-methoxyl-7-angolyl-12-hydroxylingol (7), 3,12-diacetyl-7-hydroxy-8-methoxylingol (8), and 3,12-diacetyl-7-angolyl-8-hydroxylingol (9) along with five known ingol diterpenes 2-6 and a known triterpene cyclonivulinol (1). Their structures were established by means of spectroscopic analysis. Diterpenes 2-9 were evaluated for their cytotoxic activity.
大戟科大戟属植物积雪大戟的乳汁提供了三种新的英戈尔二萜，即3-乙酰基-8-甲氧基-7-安哥拉酰基-12-羟基英戈尔（7）、3,12-二乙酰基-7-羟基-8-甲氧基英戈尔（8）和3,12-二乙酰基-7-安哥拉酰基-8-羟基英戈尔（9），以及五种已知的英戈尔二萜2-6和一种已知的三萜环积雪醇（1）。它们的结构通过光谱分析得以确定。对二萜2-9进行了细胞毒性活性评估。
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