毛萼香茶菜中的细胞毒性对映-贝壳杉烷二萜类化合物。

Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx.

作者信息

Shen Yun-Heng, Wen Zhi-Ying, Xu Gang, Xiao Wei-Lie, Peng Li-Yan, Lin Zhong-Wen, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.

出版信息

Chem Biodivers. 2005 Dec;2(12):1665-72. doi: 10.1002/cbdv.200590136.

DOI:10.1002/cbdv.200590136

PMID:17191963

Abstract

Five new ent-kaurane diterpenoids, epi-maoecrystal N (1), eriocalyxin G (2), maoecrystal W (3), maoecrystal X (4), and maoecrystal Y (5), along with 22 known ones, were isolated from Isodon eriocalyx (Dunn.) Hara., and their structures were determined by spectroscopic methods. All diterpenoids, except for 3 and 13, were evaluated for inhibition of the K562, T-24, Me180, QGY-7701, and BIU87 cell lines (Table 2).

摘要

从毛萼香茶菜（Isodon eriocalyx (Dunn.) Hara.）中分离得到了5个新的对映-贝壳杉烷二萜类化合物，表毛萼甲素N（1）、毛萼晶G（2）、毛萼晶W（3）、毛萼晶X（4）和毛萼晶Y（5），以及22个已知化合物，并通过光谱方法确定了它们的结构。除3和13外，对所有二萜类化合物进行了抑制K562、T-24、Me180、QGY-7701和BIU87细胞系活性的评估（表2）。