Shimizu M, Takdase Y, Nakamura S, Katae H, Minami A
Antimicrob Agents Chemother. 1976 Apr;9(4):569-74. doi: 10.1128/AAC.9.4.569.
Pipemidic acid, a structural relative of piromidic and nalidixic acids, exhibited substantial therapeutic activity when it was administered orally to mice bearing either widely disseminated or relatively localized infections with Staphylococcus aureus and a variety of gram-negative bacilli. The activity of pipemidic acid was always greater than that of piromidic and nalidixic acids; in infections with Pseudomonas aeruginosa and in bacilli resistant to the latter two drugs, pipemidic acid exhibited significant activity. In limited comparative studies, the activities of pipemidic acid were generally superior to the activities of cephalexin, ampicillin, and carbenicillin. Gentamicin, administered subcutaneously, was more active than pipemidic acid, given either orally or subcutaneously, against both systemic and localized infections with P. aeruginosa. The therapeutic accomplishments of pipemidic acid were attained with well-tolerated doses.
吡哌酸是吡咯米酸和萘啶酸的结构类似物，当给患有广泛播散性或相对局限性金黄色葡萄球菌及多种革兰氏阴性杆菌感染的小鼠口服时，它表现出显著的治疗活性。吡哌酸的活性总是高于吡咯米酸和萘啶酸；在铜绿假单胞菌感染以及对后两种药物耐药的杆菌感染中，吡哌酸表现出显著活性。在有限的比较研究中，吡哌酸的活性通常优于头孢氨苄、氨苄西林和羧苄西林。皮下注射庆大霉素在治疗铜绿假单胞菌的全身感染和局部感染方面比口服或皮下注射吡哌酸更具活性。吡哌酸在耐受良好的剂量下取得了治疗成效。
