AT-2266与诺氟沙星、吡哌酸、萘啶酸和庆大霉素相比，对小鼠各种实验性感染的活性。
Activity of AT-2266 compared with those of norfloxacin, pipemidic acid, nalidixic acid, and gentamicin against various experimental infections in mice.
作者信息
Nakamura S, Nakata K, Katae H, Minami A, Kashimoto S, Yamagishi J, Takase Y, Shimizu M
出版信息
Antimicrob Agents Chemother. 1983 May;23(5):742-9. doi: 10.1128/AAC.23.5.742.
Abstract
AT-2266 (1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine-3-carboxylic acid) showed marked activity in vivo when administered orally to mice bearing systemic, pulmonary, dermal, or urinary tract infections due to variety of organisms. The activity of AT-2266 was uniformly higher than those of norfloxacin, pipemidic acid, and nalidixic acid against all of the infections. The activity of AT-2266 administered orally was almost comparable to that of gentamicin administered subcutaneously against urinary tract infections due to gram-negative organisms but was generally lower against other infections. AT-2266 exhibited significant activity against infections due to gentamicin-resistant and nalidixic acid-resistant organisms.
摘要
AT - 2266（1 - 乙基 - 6 - 氟 - 1,4 - 二氢 - 4 - 氧代 - 7 - （1 - 哌嗪基）- 1,8 - 萘啶 - 3 - 羧酸）对因多种微生物引起的全身性、肺部、皮肤或尿路感染的小鼠口服给药时，在体内显示出显著活性。AT - 2266对所有感染的活性均始终高于诺氟沙星、吡哌酸和萘啶酸。口服给药的AT - 2266对革兰氏阴性菌引起的尿路感染的活性几乎与皮下注射庆大霉素的活性相当，但对其他感染的活性通常较低。AT - 2266对庆大霉素耐药和萘啶酸耐药的微生物引起的感染表现出显著活性。
相似文献
1
Activity of AT-2266 compared with those of norfloxacin, pipemidic acid, nalidixic acid, and gentamicin against various experimental infections in mice.AT-2266与诺氟沙星、吡哌酸、萘啶酸和庆大霉素相比，对小鼠各种实验性感染的活性。
Antimicrob Agents Chemother. 1983 May;23(5):742-9. doi: 10.1128/AAC.23.5.742.
2
Comparative activities of AM-715 and pipemidic and nalidixic acids against experimentally induced systemic and urinary tract infections.AM - 715与吡哌酸及萘啶酸对实验性诱导的全身感染和尿路感染的比较活性
Antimicrob Agents Chemother. 1981 Jan;19(1):188-9. doi: 10.1128/AAC.19.1.188.
3
In vitro and in vivo antibacterial activity of AT-2266.AT-2266的体外和体内抗菌活性
Antimicrob Agents Chemother. 1983 Jul;24(1):78-84. doi: 10.1128/AAC.24.1.78.
4
Pipemidic acid: its activities against various experimental infections.吡哌酸：其对各种实验性感染的作用
Antimicrob Agents Chemother. 1976 Apr;9(4):569-74. doi: 10.1128/AAC.9.4.569.
5
Incomplete cross-resistance of nalidixic and pipemidic acid-resistant variants of Serratia marcescens against ciprofloxacin, enoxacin, and norfloxacin.粘质沙雷氏菌对萘啶酸和吡哌酸耐药的变异株对环丙沙星、依诺沙星和诺氟沙星存在不完全交叉耐药性。
Chemotherapy. 1985;31(1):34-9. doi: 10.1159/000238311.
6
[Antibacterial activity of norfloxacin and pipemidic acid in a randomized double-blind study].
Minerva Urol Nefrol. 1984 Jul-Sep;36(3):247-51.
7
Laboratory evaluation of enoxacin: comparison with norfloxacin and nalidixic acid.依诺沙星的实验室评估：与诺氟沙星和萘啶酸的比较。
J Antimicrob Chemother. 1985 Jan;15(1):45-52. doi: 10.1093/jac/15.1.45.
8
In vitro activity, pharmacokinetics, clinical safety and therapeutic efficacy of enoxacin in the treatment of patients with complicated urinary tract infections.依诺沙星治疗复杂性尿路感染患者的体外活性、药代动力学、临床安全性及治疗效果
Infection. 1985 Sep-Oct;13(5):219-24. doi: 10.1007/BF01667215.
9
Clinical uses of nalidixic acid analogues: the fluoroquinolones.萘啶酸类似物的临床应用：氟喹诺酮类药物。
Eur J Clin Microbiol. 1986 Apr;5(2):138-40. doi: 10.1007/BF02013968.
10
In-vitro activity of enoxacin, ofloxacin, norfloxacin and nalidixic acid.
J Antimicrob Chemother. 1984 Sep;14 Suppl C:33-8. doi: 10.1093/jac/14.suppl_c.33.
引用本文的文献
1
In vitro activities of enoxacin and 17 other antimicrobial agents against multiply resistant, gram-negative bacteria.依诺沙星及其他17种抗菌剂对多重耐药革兰氏阴性菌的体外活性
Antimicrob Agents Chemother. 1984 Jul;26(1):97-100. doi: 10.1128/AAC.26.1.97.
2
Comparative in vitro activities of enoxacin (CI-919, AT-2266) and eleven antipseudomonal agents against aminoglycoside-susceptible and -resistant Pseudomonas aeruginosa strains.依诺沙星（CI-919，AT-2266）与十一种抗铜绿假单胞菌药物对氨基糖苷类敏感和耐药的铜绿假单胞菌菌株的体外活性比较
Antimicrob Agents Chemother. 1984 Sep;26(3):417-8. doi: 10.1128/AAC.26.3.417.
3
In vitro and in vivo antibacterial activities of the fluoroquinolone WIN 49375 (amifloxacin).氟喹诺酮类药物WIN 49375（阿米氟沙星）的体外和体内抗菌活性
Antimicrob Agents Chemother. 1985 Jan;27(1):4-10. doi: 10.1128/AAC.27.1.4.
4
Determination of pipemidic acid in plasma by normal-phase high-pressure liquid chromatography.正相高压液相色谱法测定血浆中的吡哌酸
Antimicrob Agents Chemother. 1985 Aug;28(2):192-4. doi: 10.1128/AAC.28.2.192.
5
Activity of E-3846, a new fluoroquinolone, in vitro and in experimental cystitis and pyelonephritis in rats.新型氟喹诺酮类药物E-3846在体外以及大鼠实验性膀胱炎和肾盂肾炎中的活性
Antimicrob Agents Chemother. 1988 May;32(5):636-41. doi: 10.1128/AAC.32.5.636.
6
In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone.新型广谱喹诺酮类药物AT-4140的体外和体内抗菌活性
Antimicrob Agents Chemother. 1989 Aug;33(8):1167-73. doi: 10.1128/AAC.33.8.1167.
7
In vivo evaluation of NM441, a new thiazeto-quinoline derivative.新型噻唑并喹啉衍生物NM441的体内评价
Antimicrob Agents Chemother. 1991 Dec;35(12):2496-9. doi: 10.1128/AAC.35.12.2496.
8
In vitro antibacterial activity of a new quinolone, NM394.新型喹诺酮NM394的体外抗菌活性
Antimicrob Agents Chemother. 1991 Dec;35(12):2490-5. doi: 10.1128/AAC.35.12.2490.
本文引用的文献
1
Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids.抗菌性6,7 - 及7,8 - 二取代1 - 烷基 - 1,4 - 二氢 - 4 - 氧代喹啉 - 3 - 羧酸的构效关系
J Med Chem. 1980 Dec;23(12):1358-63. doi: 10.1021/jm00186a014.
2
Comparative activities of AM-715 and pipemidic and nalidixic acids against experimentally induced systemic and urinary tract infections.AM - 715与吡哌酸及萘啶酸对实验性诱导的全身感染和尿路感染的比较活性
Antimicrob Agents Chemother. 1981 Jan;19(1):188-9. doi: 10.1128/AAC.19.1.188.
3
In vitro antibacterial activity of AM-715, a new nalidixic acid analog.新型萘啶酸类似物AM - 715的体外抗菌活性
Antimicrob Agents Chemother. 1980 Feb;17(2):103-8. doi: 10.1128/AAC.17.2.103.
4
In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.喹诺酮羧酸类药物诺氟沙星的体外活性与β-内酰胺类、氨基糖苷类及甲氧苄啶的比较。
Antimicrob Agents Chemother. 1982 Jul;22(1):23-7. doi: 10.1128/AAC.22.1.23.
5
In vitro antibacterial activity of norfloxacin (MK-0366).诺氟沙星（MK-0366）的体外抗菌活性
Antimicrob Agents Chemother. 1982 Apr;21(4):604-7. doi: 10.1128/AAC.21.4.604.
6
Pipemidic acid: its activities against various experimental infections.吡哌酸：其对各种实验性感染的作用
Antimicrob Agents Chemother. 1976 Apr;9(4):569-74. doi: 10.1128/AAC.9.4.569.
7
Pipemidic acid, a new antibacterial agent active against Pseudomonas aeruginosa: in vitro properties.吡哌酸，一种对铜绿假单胞菌有效的新型抗菌剂：体外特性
Antimicrob Agents Chemother. 1975 Aug;8(2):132-8. doi: 10.1128/AAC.8.2.132.
8
Pyrido(2,3-d)pyrimidine antibacterial agents. 3. 8-Alkyl- and 8-vinyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acids and their derivatives.吡啶并(2,3 - d)嘧啶类抗菌剂。3. 8 - 烷基和8 - 乙烯基 - 5,8 - 二氢 - 5 - 氧代 - 2 - (1 - 哌嗪基)吡啶并(2,3 - d)嘧啶 - 6 - 羧酸及其衍生物。
J Med Chem. 1975 Jan;18(1):74-9. doi: 10.1021/jm00235a017.
Zotero 插件