吡哌酸，一种对铜绿假单胞菌有效的新型抗菌剂：体外特性
Pipemidic acid, a new antibacterial agent active against Pseudomonas aeruginosa: in vitro properties.
作者信息
Shimizu M, Takase Y, Nakamura S, Katae H, Minami A
出版信息
Antimicrob Agents Chemother. 1975 Aug;8(2):132-8. doi: 10.1128/AAC.8.2.132.
Abstract
Pipemidic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-pyrido [2,3-d]pyrimidine-6-carboxylic acid, is a new derivative of piromidic acid. It is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Its potency is generally greater than that of piromidic acid and nalidixic acid. Cross-resistance is not observed between pipemidic acid and various antibiotics, and most of bacteria resistant to piromidic acid and nalidixic acid are moderately susceptible to pipemidic acid. The activity of pipemidic acid is scarcely affected by the addition of serum, sodium cholate, or change of medium pH, but is subject to the influence of inoculum size. Its action is bactericidal above minimal inhibitory concentrations.
摘要
吡哌酸，8-乙基-5,8-二氢-5-氧代-2-(1-哌嗪基)吡啶并[2,3-d]嘧啶-6-羧酸，是吡咯米酸的一种新衍生物。它对包括铜绿假单胞菌在内的革兰氏阴性菌以及一些革兰氏阳性菌具有活性。其效力通常大于吡咯米酸和萘啶酸。在吡哌酸与各种抗生素之间未观察到交叉耐药性，并且大多数对吡咯米酸和萘啶酸耐药的细菌对吡哌酸中度敏感。吡哌酸的活性几乎不受血清、胆酸钠添加或培养基pH值变化的影响，但受接种量大小的影响。在最低抑菌浓度以上其作用是杀菌性的。
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