Jackson Reuben, Pencharz Paul B
Department of Paediatrics, Division of GI/Nutrition, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ont., Canada M5G 1X8.
Best Pract Res Clin Gastroenterol. 2003 Apr;17(2):213-35. doi: 10.1016/s1521-6918(02)00150-6.
Advancement in treatment has resulted in a dramatic increase in life expectancy of patients with cystic fibrosis (CF) to well beyond 30 years of age in most centres. What was once a fatal genetic disease in childhood now sees over a third of its CF populations in adult clinics. The improved survival is multifactorial, but most attribute the reasons to more aggressive nutritional care along with better management of the gastrointestinal and pulmonary systems. Many of the nutritional and GI issues of paediatric patients remain similar when they become adults, except that there is the added psychosocial stress associated with this transition. This chapter aims to highlight the gastrointestinal and nutritional issues manifesting at the different stages of life from infancy to adulthood, and the recommended management.
治疗方面的进展已使囊性纤维化(CF)患者的预期寿命显著延长,在大多数中心,患者的预期寿命已远超30岁。曾经在儿童期是致命的遗传性疾病,如今在成人诊所中,超过三分之一的CF患者群体已步入成年。生存率的提高是多因素的,但大多数人将其归因于更积极的营养护理以及对胃肠道和肺部系统的更好管理。儿科患者成年后,许多营养和胃肠道问题仍然相似,只是这种转变还伴随着额外的心理社会压力。本章旨在突出从婴儿期到成年期不同生命阶段出现的胃肠道和营养问题以及推荐的管理方法。