Caglayan F, Caglayan O, Gunel E, Sahin T K
Department of Pediatric Surgery, Medical Faculty, Kirikkale University, 71100 Kirikkale, Turkey.
Int J Surg Investig. 2000;2(4):309-12.
Visceral proteins and acute phase reactants have commonly been used as indicators of nutritional status, and metabolic response of surgical trauma.
This study was undertaken to determine how some plasma proteins, alone or together reflect metabolic response in neonates recovering from major surgery.
Serum albumin, pre-albumin (PA), C-reactive protein (CRP), and alpha1-acid glycoprotein (AGP) levels were measured, and the prognostic inflammatory and nutritional index (PINI) was calculated for preoperative day 1 (-1) and postoperative (PO) days 1 (+1) and 7 (+7).
PA, CRP, AGP and PINI were significantly different on day +1 from day -1. While AGP and PINI were still significantly higher than that of day -1, PA and CRP returned to the preoperative levels on day +7.
PA, CRP and AGP measurements are superior to PINI for assessing postoperative metabolic changes in term neonates following uncomplicated major surgery on early and late phase. But this comparison must be performed in the management of more complex cases to determine which one is better to indicate morbidity and mortality.
内脏蛋白和急性期反应物通常被用作营养状况以及手术创伤代谢反应的指标。
本研究旨在确定某些血浆蛋白单独或共同反映从大手术中恢复的新生儿代谢反应的方式。
测量血清白蛋白、前白蛋白（PA）、C反应蛋白（CRP）和α1-酸性糖蛋白（AGP）水平，并计算术前第1天（-1）、术后第1天（+1）和第7天（+7）的预后炎症和营养指数（PINI）。
+1天的PA、CRP、AGP和PINI与-1天有显著差异。虽然AGP和PINI仍显著高于-1天，但PA和CRP在+7天恢复到术前水平。
对于评估足月儿在进行无并发症大手术后早期和晚期的术后代谢变化，PA、CRP和AGP测量优于PINI。但在处理更复杂病例时必须进行这种比较，以确定哪一种更能指示发病率和死亡率。
