Cal C, Garban H, Jazirehi A, Yeh C, Mizutani Y, Bonavida B
Department of Microbiology, UCLA School of Medicine, University of California, Los Angeles 90095, USA.
Curr Med Chem Anticancer Agents. 2003 Mar;3(2):77-93. doi: 10.2174/1568011033353443.
The polyphenolic compound Resveratrol is a naturally occurring phytochemical and can be found in many plant species, including grapes, peanuts and various herbs. Several studies have established that Resveratrol can exert anti-oxidant and anti-inflammatory activities. It also has activity in the regulation of multiple cellular events associated with carcinogenesis. This review describes the general properties of Resveratrol including its relationship to estrogen, its effect on lipid metabolism, its cardiovascular effects, and its role on gene expression. Resveratrol has also been examined in several model systems for its potential effect against cancer. Its anti-cancer effects include its role as a chemopreventive agent, its ability to inhibit cell proliferation, its direct effect in cytotoxicity by induction of apoptosis and on its potential therapeutic effect in pre-clinical studies. In addition, Resveratrol has been shown to exert sensitization effects on cancer cells that will result in a synergistic cytotoxic activity when Resveratrol is used in combination with cytotoxic drugs in drug-resistant tumor cells. Clearly, the studies with Resveratrol provide support for the use of Resveratrol in human cancer chemoprevention and combination with chemotherapeutic drugs or cytotoxic factors in the treatment of drug refractory tumor cells.
多酚类化合物白藜芦醇是一种天然存在的植物化学物质，存在于许多植物物种中，包括葡萄、花生和各种草药。多项研究证实，白藜芦醇具有抗氧化和抗炎活性。它在调节与致癌作用相关的多种细胞事件中也具有活性。本综述描述了白藜芦醇的一般特性，包括其与雌激素的关系、对脂质代谢的影响、对心血管的影响以及在基因表达中的作用。白藜芦醇在几种模型系统中也因其对癌症的潜在作用而受到研究。其抗癌作用包括作为化学预防剂的作用、抑制细胞增殖的能力、通过诱导凋亡产生的细胞毒性直接作用以及在临床前研究中的潜在治疗作用。此外，白藜芦醇已被证明对癌细胞具有致敏作用，当白藜芦醇与细胞毒性药物联合用于耐药肿瘤细胞时，会产生协同细胞毒性活性。显然，对白藜芦醇的研究为白藜芦醇用于人类癌症化学预防以及与化疗药物或细胞毒性因子联合用于治疗难治性肿瘤细胞提供了支持。
