Lindelius Anna, Varli Ingela Hulthén, Hammarström Margareta
Karolinska Institutet, Department of Obstetrics and Gynaecology at Stockholm Söder Hospital, S-118 83, Stockholm, Sweden.
Contraception. 2003 Apr;67(4):299-303. doi: 10.1016/s0010-7824(02)00538-3.
To study the effect and complication rate of lamicel versus gemeprost as pretreatment to vacuum aspiration for the interruption of early pregnancy, the files of 622 medical records of women having a first-trimester abortion at Söder Hospital were studied retrospectively. Group A consisted of 317 women treated with lamicel in 1995 and Group B of 305 women treated with gemeprost in 1996. Complications were more common in Group A than in Group B (55 vs. 22; p < 0.05). Re-admission took place more often in Group A (25) than in Group B (6) (p < 0.05). The complications were more severe in Group A than in Group B. Using multivariate logistic regression analysis, the only impact factor for having a complication was the use of product for cervical priming. Gemeprost for preoperative treatment was found to render a fairly low rate of complications in this study, while complication rate was higher after treatment with lamicel.
为研究米索前列醇与吉美前列素作为早期妊娠终止真空吸引术前预处理的效果及并发症发生率，我们回顾性研究了索德医院622例孕早期流产女性的病历档案。A组由1995年接受米索前列醇治疗的317名女性组成，B组由1996年接受吉美前列素治疗的305名女性组成。A组并发症比B组更常见（55例 vs. 22例；p < 0.05）。A组再次入院的情况比B组更频繁（25例 vs. 6例）（p < 0.05）。A组并发症比B组更严重。使用多因素逻辑回归分析，发生并发症的唯一影响因素是用于宫颈准备的药物。在本研究中，术前使用吉美前列素的并发症发生率相当低，而使用米索前列醇治疗后的并发症发生率更高。
