Vlajinac H D, Pekmezović T D, Adanja B J, Marinković J M, Kanazir M S, Suvajdzić N D, Colović M D
Institute of Epidemiology, School of Medicine, University of Belgrade, Yugoslavia.
Neoplasma. 2003;50(1):79-83.
The case-control study was conducted in Belgrade (Yugoslavia) during the period 1994-1998. The objective of the study was to investigate factors related to the occurrence of multiple myeloma (MM). The study group consisted of 100 newly diagnosed MM patients and the same number of matched hospital controls. In the analysis conditional univariate and multivariate logistic regression were applied. According to multivariate analysis the following factors were significantly related to MM: smoking > or =25 cigarettes per day (Odds ratio--OR=6.7, 95% confidence interval--95% CI=1.3-34.3); having more than two brothers (OR=2.7, 95% CI=1.3-5.3), rheumatoid arthritis in personal history (OR=4.2, 95% CI=1.2-14.8), and frequent (4-7 times per week vs. lower frequency) consumption of yogurt (OR=3.1, 95% CI=1.6-6.0) and vegetables (OR=0.4, 95% CI=0.1-1.0).
1994年至1998年期间，在贝尔格莱德（南斯拉夫）开展了一项病例对照研究。该研究的目的是调查与多发性骨髓瘤（MM）发病相关的因素。研究组由100名新诊断的MM患者和数量相同的匹配医院对照组成。分析中应用了条件单变量和多变量逻辑回归。根据多变量分析，以下因素与MM显著相关：每天吸烟≥25支（比值比——OR = 6.7，95%置信区间——95%CI = 1.3 - 34.3）；有两个以上兄弟（OR = 2.7，95%CI = 1.3 - 5.3），个人病史中有类风湿性关节炎（OR = 4.2，95%CI = 1.2 - 14.8），以及频繁（每周4 - 7次与较低频率相比）食用酸奶（OR = 3.1，95%CI = 1.6 - 6.0）和蔬菜（OR = 0.4，95%CI = 0.1 - 1.0）。
