Perbellini Luigi, Princivalle Andrea, Cerpelloni Marzia, Pasini Francesco, Brugnone Francesco
Occupational Medicine Service, Department of Medicine and Public Health, Policlinico GB Rossi, University of Verona, 37134 Verona, Italy. perbelui@.univr.it
Int Arch Occup Environ Health. 2003 Jul;76(6):461-6. doi: 10.1007/s00420-003-0436-7. Epub 2003 Apr 10.
To investigate and compare alveolar, blood, and urine concentrations of 1,3-butadiene, 2,5 dimethylfuran, and benzene, in non-occupational exposure to these products.
Benzene, 2,5-dimethylfuran and 1,3-butadiene were measured in the breath, blood, and urine samples of 61 subjects living in small mountain villages. All 61 were regularly employed as forestry workers. Sampling was done during the long winter-season non-working period. Samples were collected after overnight rest and analysed by headspace and GC-mass spectrometry methods.
The median 1,3-butadiene level was 1.2 ng/l (range: <0.8-13.2 ng/l) in alveolar air, 2.2 ng/l (range: <0.5-50.2 ng/l) in blood, and 1.1 ng/l (range: <1-8.9 ng/l) in urine. The median benzene level was 5.7 ng/l (range: <1-24.9 ng/l) in alveolar air, 62.3 ng/l (range: 33.5-487.2 ng/l) in blood, and 63.4 ng/l (range: 25.8-1099.1 ng/l) in urine. The median 2,5-dimethylfuran level was 0.5 ng/l (range: <1-12.5 ng/l) in alveolar air, 2.5 ng/l (range: <5-372.9 ng/l) in blood, and 51.8 ng/l (range: <5-524.9 ng/l) in urine. In several cases, 2,5-dimethylfuran levels were below the detection limit in alveolar air and blood, especially in non-smokers. 1,3-Butadiene, 2,5-dimethylfuran and benzene levels were significantly higher in smokers than non-smokers in all biological media.
1,3-Butadiene and benzene, as ubiquitous pollutants, are detectable and quantifiable in human alveolar air, blood and urine. 2,5-Dimethylfuran, which is not a usual environmental pollutant, is almost always detectable in biological media, but only in smokers.
调查并比较在非职业接触这些物质的情况下,1,3 - 丁二烯、2,5 - 二甲基呋喃和苯在肺泡、血液及尿液中的浓度。
对居住在小山村的61名受试者的呼吸、血液和尿液样本中的苯、2,5 - 二甲基呋喃和1,3 - 丁二烯进行检测。这61人均为林业工人。采样在漫长的冬季非工作期间进行。样本在过夜休息后采集,并通过顶空和气相色谱 - 质谱联用方法进行分析。
肺泡气中1,3 - 丁二烯的中位数水平为1.2纳克/升(范围:<0.8 - 13.2纳克/升),血液中为2.2纳克/升(范围:<0.5 - 50.2纳克/升),尿液中为1.1纳克/升(范围:<1 - 8.9纳克/升)。肺泡气中苯的中位数水平为5.7纳克/升(范围:<1 - 24.9纳克/升),血液中为62.3纳克/升(范围:33.5 - 487.2纳克/升),尿液中为63.4纳克/升(范围:25.8 - 1099.1纳克/升)。肺泡气中2,5 - 二甲基呋喃的中位数水平为0.5纳克/升(范围:<1 - 12.5纳克/升),血液中为2.5纳克/升(范围:<5 - 372.9纳克/升),尿液中为51.8纳克/升(范围:<5 - 524.9纳克/升)。在一些情况下,肺泡气和血液中2,5 - 二甲基呋喃的水平低于检测限,尤其是在不吸烟者中。在所有生物介质中,吸烟者的1,3 - 丁二烯、2,5 - 二甲基呋喃和苯水平均显著高于不吸烟者。
1,3 - 丁二烯和苯作为普遍存在的污染物,在人体肺泡气、血液和尿液中可被检测和定量。2,5 - 二甲基呋喃并非常见的环境污染物,在生物介质中几乎总能被检测到,但仅在吸烟者中。