Department of Chemistry, An-Najah National University, Nablus P.O. Box 7, Palestine.
Groupe de Spectrométrie Moléculaire et Atmosphérique GSMA, UMR CNRS 7331, Université de Reims, Moulin de la Housse B.P. 1039, CEDEX 02, 51687 Reims, France.
Int J Environ Res Public Health. 2023 Apr 23;20(9):5613. doi: 10.3390/ijerph20095613.
Volatile organic compounds (VOCs) are considered a major public health concern in industrial location areas. The presence of exposure to (VOCs) has raised concern regarding the health effects caused by chronic human exposure as this will increase cancer diseases in the village. An analytical method has been developed and modified to help us detect 38 VOCs in the blood of 38 volunteers who are related to a carpentry shop at the parts-per-trillion level. To measure and evaluate the potential risk, several devices, such as portable passive monitors and air-collected samples, in addition to blood concentration, were used to study three different occupational groups. Ten of the volunteers are employees at the shop, 10 volunteers live very close to the shop, and 10 of them are students in an elementary school very close to the shop. In this study, we developed an automated analytical method using headspace (HS) together with solid-phase microextraction (SPME) connected to capillary gas chromatography (GC) equipped with quadrupole mass spectrometry (MS). The detection limits for the method used were measured in the range from 0.001 to 0.15 ng/L, using linear calibration curves that have three orders of magnitude. The detected concentrations ranged from 3 ng L for trichloroethene to 91 ng L for toluene and 270 ng L for 2,4-diisocyanate, which was derived from the paint solvents used for the wood in the carpentry shop and the paints on the walls. More than half of all assessed species (80%) had mean concentration values less than 50 ng L, which is the maximum allowed for most VOCs. The major chemical types among the compounds quantified will be those we found in our previous study in the surrounding air of a carpentry workshop in Deir Ballout in Palestine, which were toluene diisocyanate and butyl cyanate. Some were found to be highly present air. Most of the measurements were below the guidelines of the World Health Organization (WHO). Despite the fact that this study only involved a small number of smokers, smoking was found to be connected with several blood and breath components. This group includes unsaturated hydrocarbons (1,3-butadiene, 1,3-pentadiene, 2-butene), furans (2,5-dimethylfuran), and acetonitrile. The proposed classification of measured species into systemic (blood-borne) and exogenous volatiles is strictly hypothetical, as some species may have several origins.
挥发性有机化合物 (VOCs) 被认为是工业选址地区的主要公共卫生问题。由于接触 (VOCs) 会导致慢性人类暴露引起的健康影响，因此增加了村庄中癌症疾病的风险。已经开发并修改了一种分析方法，以帮助我们在与木工店相关的 38 名志愿者的血液中检测到 38 种 VOC，检测限低至 ppt 级。为了测量和评估潜在风险，使用了几种设备，例如便携式被动监测器和空气收集样本，以及血液浓度，来研究三个不同的职业群体。其中 10 名志愿者是商店的员工，10 名志愿者住在商店附近，10 名志愿者是商店附近小学的学生。在这项研究中，我们开发了一种自动化分析方法，使用顶空 (HS) 与固相微萃取 (SPME) 相结合，连接到配备四极杆质谱 (MS) 的毛细管气相色谱 (GC)。所使用的方法的检测限在 0.001 到 0.15 ng/L 之间，使用具有三个数量级的线性校准曲线进行测量。检测到的浓度范围从三氯乙烯的 3 ng/L 到甲苯的 91 ng/L 和 2,4-二异氰酸酯的 270 ng/L，这是源自木工店木材使用的油漆溶剂和墙壁上的油漆。评估的物种中超过一半（80%）的平均浓度值低于 50 ng/L，这是大多数 VOC 允许的最大值。在量化的化合物中，主要的化学类型将是我们在巴勒斯坦 Deir Ballout 的木工车间周围空气中进行的先前研究中发现的那些，即甲苯二异氰酸酯和丁基异氰酸酯。有些被发现是空气中高度存在的。大多数测量值都低于世界卫生组织 (WHO) 的指导方针。尽管这项研究仅涉及少数吸烟者，但吸烟与几种血液和呼吸成分有关。这一组包括不饱和烃（1,3-丁二烯、1,3-戊二烯、2-丁烯）、呋喃（2,5-二甲基呋喃）和乙腈。将测量的物种分为系统性（血液传播）和外源性挥发物的分类是严格假设的，因为一些物种可能有多个来源。
