Turberfield A J, Mitchell J C, Yurke B, Mills A P, Blakey M I, Simmel F C
University of Oxford, Department of Physics, Clarendon Laboratory, Parks Road, Oxford OX1 3PU, United Kingdom.
Phys Rev Lett. 2003 Mar 21;90(11):118102. doi: 10.1103/PhysRevLett.90.118102. Epub 2003 Mar 18.
We describe kinetic control of DNA hybridization: loop complexes are used to inhibit the hybridization of complementary oligonucleotides; rationally designed DNA catalysts are shown to be effective in promoting their hybridization. This is the basis of a strategy for using DNA as a fuel to drive free-running artificial molecular machines.
我们描述了DNA杂交的动力学控制:环状复合物用于抑制互补寡核苷酸的杂交;合理设计的DNA催化剂被证明能有效地促进它们的杂交。这是一种将DNA用作燃料来驱动自主运行的人工分子机器的策略的基础。