Marshall Jonathon C, Powell Jeffrey R, Caccone Adalgisa
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 96520-8105, USA.
Am J Trop Med Hyg. 2005 Oct;73(4):749-52.
Malaria kills more than one million people a year, and understanding the historical association between its most notorious causative agent, Plasmodium falciparum, and its mosquito vectors is important in fighting the disease. We present a phylogenetic analysis of a number of species within the mosquito subgenus Cellia based on a selection of mitochondrial and nuclear genes. Although some of these relationships have been estimated in other studies, generally few species were included and/or statistical support at many nodes was low. Here we include two additional species of anthropophilic P. falciparum malaria vectors and reanalyze these relationships using a Bayesian method that allows us to simultaneously incorporate different models of evolution. We report data that indicate a paraphyletic relationship between five anthropophilic African mosquito vectors. Such a relationship suggests that these species can serve as independent natural experiments for anopheline immunologic responses to regular, prolonged contact with P. falciparum.
疟疾每年导致超过一百万人死亡，了解其最臭名昭著的病原体恶性疟原虫与其蚊媒之间的历史关联对于抗击这种疾病至关重要。我们基于一系列线粒体和核基因，对疟蚊亚属塞利阿（Cellia）中的多个物种进行了系统发育分析。尽管其他研究已经对其中一些关系进行了估计，但通常纳入的物种较少，并且/或者许多节点的统计支持率较低。在这里，我们纳入了另外两种嗜人恶性疟原虫疟疾的蚊媒物种，并使用贝叶斯方法重新分析这些关系，该方法使我们能够同时纳入不同的进化模型。我们报告的数据表明，五种非洲嗜人蚊媒之间存在并系关系。这种关系表明，这些物种可作为按蚊对与恶性疟原虫定期、长期接触的免疫反应的独立自然实验。
