Naus Cynthia W A, Jones Frances M, Satti Mohamed Z, Joseph Sarah, Riley Eleanor M, Kimani Gachuhi, Mwatha Joseph K, Kariuki Curtis H, Ouma John H, Kabatereine Narcis B, Vennervald Birgitte J, Dunne David W
Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
J Infect Dis. 2003 Apr 15;187(8):1272-82. doi: 10.1086/368361. Epub 2003 Apr 2.
We examined specific immunoglobulin G1 (IgG1) and IgG3 responses to Plasmodium falciparum schizont and Schistosoma mansoni egg and worm antigens in individuals from Kenya, Uganda, and the Sudan who had been exposed to malaria and schistosomiasis. A strong correlation between malaria- and schistosome-specific IgG3 responses was observed. This association appears to result from the presence of cross-reactive components of the 2 parasites that bind IgG3 antibodies, rather than to be mediated by immunological cross-regulation or specific regulatory mechanisms induced by either parasite. Cross-reactivity of IgG3 antibodies was confirmed in a Brazilian cohort of individuals living in an area where schistosomiasis is endemic but no malaria occurs and in a Pakistani cohort from an area where malaria is endemic but no schistosomiasis occurs. An IgG3 interaction with antigens from both parasites was observed in individuals from both cohorts, but not in uninfected European control subjects. The immunological and biological implications of this observation require further exploration.
我们检测了来自肯尼亚、乌干达和苏丹的曾接触过疟疾和血吸虫病的个体对恶性疟原虫裂殖体以及曼氏血吸虫虫卵和虫体抗原的特异性免疫球蛋白G1（IgG1）和IgG3反应。观察到疟疾特异性和血吸虫特异性IgG3反应之间存在强相关性。这种关联似乎是由于两种寄生虫存在结合IgG3抗体的交叉反应成分，而非由免疫交叉调节或任一寄生虫诱导的特异性调节机制介导。在生活于血吸虫病流行但无疟疾地区的巴西人群体以及生活于疟疾流行但无血吸虫病地区的巴基斯坦人群体中，均证实了IgG3抗体的交叉反应性。在这两个群体的个体中均观察到IgG3与两种寄生虫的抗原发生相互作用，但在未感染的欧洲对照受试者中未观察到这种现象。这一观察结果的免疫学和生物学意义有待进一步探究。
