Chen Zheng W, Letvin Norman L
Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE113/RE216, Boston, MA 02115, USA.
Trends Immunol. 2003 Apr;24(4):213-9. doi: 10.1016/s1471-4906(03)00032-2.
The role of gammadelta T cells in adaptive immunity remains uncertain. Recent studies have demonstrated that a unique subset of gammadelta T cells in primates can mount adaptive immune responses during mycobacterial infections. This Review discusses notable similarities and differences in adaptive immune responses between non-peptide-specific gammadelta T cells and peptide-specific alphabeta T cells, and discusses both the molecular basis for gammadelta T-cell responses and potential functions of these enigmatic cells.
γδ T细胞在适应性免疫中的作用仍不明确。最近的研究表明，灵长类动物中γδ T细胞的一个独特亚群在分枝杆菌感染期间可引发适应性免疫反应。本综述讨论了非肽特异性γδ T细胞和肽特异性αβ T细胞在适应性免疫反应中的显著异同，并探讨了γδ T细胞反应的分子基础以及这些神秘细胞的潜在功能。
