• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

对自发性糖尿病中国仓鼠小肠形态学变化的研究。

A study of the morphological changes in the small intestine of the spontaneously diabetic Chinese hamster.

作者信息

Diani A R, Gerritsen G C, Stromsta S, Murray P

出版信息

Diabetologia. 1976 May;12(2):101-9. doi: 10.1007/BF00428973.

DOI:10.1007/BF00428973
PMID:1269845
Abstract

Several morphological changes were observed microscopically in the small intestine of some diabetic Chinese hamsters. Although some alterations lacked statistical significance due to variation, most diabetics displayed a greater incidence and severity compared with nondiabetic controls. The following structural deviations were seen in the small intestines of some diabetics: increased surface area, elevated number of goblet cells per villus, decreased muscle thickness with connective tissue infiltration, reduced number of Auerbach's plexuses, lymphocyte aggregations accompanied by blunted villi, blood vascular lesions and deformed villi due to excessive loss of epithelial cells.

摘要

在一些患有糖尿病的中国仓鼠的小肠中,显微镜下观察到了几种形态学变化。尽管由于个体差异,一些改变缺乏统计学意义,但与非糖尿病对照组相比,大多数糖尿病仓鼠的这些变化发生率更高、程度更严重。在一些糖尿病仓鼠的小肠中观察到以下结构异常:表面积增加、每根绒毛杯状细胞数量增多、肌肉厚度减小伴有结缔组织浸润、奥尔巴赫神经丛数量减少、淋巴细胞聚集伴有绒毛变钝、血管病变以及由于上皮细胞过度丢失导致的绒毛变形。

相似文献

1
A study of the morphological changes in the small intestine of the spontaneously diabetic Chinese hamster.对自发性糖尿病中国仓鼠小肠形态学变化的研究。
Diabetologia. 1976 May;12(2):101-9. doi: 10.1007/BF00428973.
2
Identification of hydroxyapatite deposits in the smooth muscle cells and ganglion cells of autopsied small intestines.在尸检小肠的平滑肌细胞和神经节细胞中鉴定羟基磷灰石沉积物。
J Med Dent Sci. 2004 Jun;51(2):129-38.
3
Radiologic abnormalities and autonomic neuropathology in the digestive tract of the ketonuric diabetic Chinese hamster.酮尿性糖尿病中国仓鼠消化道的放射学异常与自主神经病理学
Diabetologia. 1979 Jul;17(1):33-40. doi: 10.1007/BF01222975.
4
Injury to myenteric plexus of intestinal segments after vascular pedicle interruption: an experimental study in rats and rabbits.
J Nihon Univ Sch Dent. 1997 Mar;39(1):17-24. doi: 10.2334/josnusd1959.39.17.
5
Myenteric plexus destruction alters morphology of rat intestine.
Gastroenterology. 1993 Oct;105(4):1017-28. doi: 10.1016/0016-5085(93)90944-8.
6
Structural and functional characteristics of muscle from diabetic rodent small intestine.糖尿病啮齿动物小肠肌肉的结构和功能特征
Am J Physiol. 1990 May;258(5 Pt 1):G690-8. doi: 10.1152/ajpgi.1990.258.5.G690.
7
Morphological alterations in small intestine of rats with myenteric plexus denervation.肠肌丛去神经大鼠小肠的形态学改变
Eur Surg Res. 2004 May-Jun;36(3):152-8. doi: 10.1159/000077257.
8
Capillary basement membrane thickening associated with the small intestine of the ketonuric diabetic Chinese hamster.与酮尿性糖尿病中国仓鼠小肠相关的毛细血管基底膜增厚。
Lab Invest. 1981 Apr;44(4):388-91.
9
Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice.高脂饮食诱导的小鼠小肠肠道和神经肌层适应性变化
BMC Gastroenterol. 2015 Jan 22;15:3. doi: 10.1186/s12876-015-0228-z.
10
Intestinal Auerbach plexus structures with NADH histochemistry in three strains of spontaneous diabetic rats.用NADH组织化学法观察三种自发性糖尿病大鼠品系的肠道奥尔巴赫神经丛结构
Acta Gastroenterol Latinoam. 2007 Jun;37(2):91-8.

引用本文的文献

1
Ravages of Diabetes on Gastrointestinal Sensory-Motor Function: Implications for Pathophysiology and Treatment.糖尿病对胃肠感觉运动功能的损害:对病理生理学和治疗的启示。
Curr Gastroenterol Rep. 2016 Feb;18(2):6. doi: 10.1007/s11894-015-0481-x.
2
Diabetic gastrointestinal motility disorders and the role of enteric nervous system: current status and future directions.糖尿病性胃肠动力障碍与肠神经系统的作用:现状与未来方向
Neurogastroenterol Motil. 2014 May;26(5):611-24. doi: 10.1111/nmo.12330. Epub 2014 Mar 24.
3
Morphofunctional changes underlying intestinal dysmotility in diabetic RIP-I/hIFNβ transgenic mice.

本文引用的文献

1
HISTOLOGICAL CHANGES IN THE SMALL BOWEL IN DIABETES MELLITUS; A STUDY OF PERORAL BIOPSY SPECIMENS.
Acta Pathol Microbiol Scand. 1965;63:478-80. doi: 10.1111/apm.1965.63.3.478.
2
Diabetes mellitus associated with nontropical sprue. Report of four cases.
Diabetes. 1962 Sep-Oct;11:388-92.
3
The intestinal tract in diabetic diarrhea; a pathologic study.糖尿病性腹泻中的肠道;一项病理学研究。
Diabetes. 1956 Jul-Aug;5(4):289-94. doi: 10.2337/diab.5.4.289.
4
糖尿病 RIP-I/hIFNβ 转基因小鼠肠动力障碍的形态功能变化。
Int J Exp Pathol. 2011 Dec;92(6):400-12. doi: 10.1111/j.1365-2613.2011.00789.x. Epub 2011 Nov 3.
4
Cellular pathogenesis of diabetic gastroenteropathy.糖尿病性胃肠病的细胞发病机制
Minerva Gastroenterol Dietol. 2009 Sep;55(3):315-43.
5
Morphometric analysis of autonomic neuropathology in the abdominal sympathetic trunk of the ketonuric diabetic Chinese hamster.酮尿性糖尿病中国仓鼠腹部交感干自主神经病理学的形态计量分析
Acta Neuropathol. 1981;53(4):293-8. doi: 10.1007/BF00690371.
6
Peripheral neurology of the diabetic Chinese hamster.中国糖尿病仓鼠的周围神经学
Diabetologia. 1982 Nov;23(5):445-51. doi: 10.1007/BF00260960.
7
Islet innervation of nondiabetic and diabetic Chinese hamsters. I. Acetylcholinesterase histochemistry and norepinephrine fluorescence.非糖尿病和糖尿病中国仓鼠的胰岛神经支配。I. 乙酰胆碱酯酶组织化学和去甲肾上腺素荧光
J Neural Transm. 1983;56(2-3):223-38. doi: 10.1007/BF01243280.
8
Radiologic abnormalities and autonomic neuropathology in the digestive tract of the ketonuric diabetic Chinese hamster.酮尿性糖尿病中国仓鼠消化道的放射学异常与自主神经病理学
Diabetologia. 1979 Jul;17(1):33-40. doi: 10.1007/BF01222975.
Gastrointestinal manifestations of diabetes.
糖尿病的胃肠道表现
N Engl J Med. 1966 Dec 15;275(24):1350-61. doi: 10.1056/NEJM196612152752406.
5
Small bowel motility in diabetics.糖尿病患者的小肠动力
Am J Dig Dis. 1969 Mar;14(3):163-9. doi: 10.1007/BF02235877.
6
Characterization of diabetes in the Chinese hamster.中国仓鼠糖尿病的特征描述。
Diabetologia. 1967 Apr;3(2):74-84. doi: 10.1007/BF01222182.
7
Diabetic diarrhea and steatorrhea. Microbiologic and clinical observations.糖尿病性腹泻和脂肪泻。微生物学及临床观察。
Ann Intern Med. 1970 Feb;72(2):215-8. doi: 10.7326/0003-4819-72-2-215.
8
Abnormal secretion of insulin and glucagon by the in vitro perfused pancreas of the genetically diabetic Chinese hamster.遗传性糖尿病中国仓鼠的体外灌注胰腺中胰岛素和胰高血糖素的异常分泌。
J Clin Invest. 1974 Jun;53(6):1637-46. doi: 10.1172/JCI107714.
9
Enhanced intestinal fat absorption in diabetic chinese hamsters.糖尿病中国仓鼠肠道脂肪吸收增强。
Diabetologia. 1973 Dec;9(6):505-8. doi: 10.1007/BF00461697.
10
Morphologic changes in the aorta of the diabetic Chinese hamster.
Diabetologia. 1974 Nov;10 Suppl:601-6. doi: 10.1007/BF01221992.