Diani A R, Grogan D M, Yates M E, Risinger D L, Gerritsen G C
Diabetologia. 1979 Jul;17(1):33-40. doi: 10.1007/BF01222975.
Barium x-ray patterns of ketonuric diabetic Chinese hamsters displayed marked dilatation of the stomach, small and large intestine. Hypomotility was manifested by flocculation of barium in the small and large bowel. Impaired transit time was further characterized by prolonged emptying of the stomach (mean 570 min diabetics; 200 min controls) and delayed stool formation (mean 230 min diabetics; and 100 min controls) and passage (mean 457 min diabetics; 210 min controls). Ultrastructural analysis of Auerbach's myenteric plexuses of the small intestine indicated acute degeneration in certain distal, unmyelinated axons. Swelling, deposition of glycogen, aggregation of neurofilaments and dense accumulation of lamellar bodies were observed. The severity and frequency of barium flocculation, glycogen deposition, aggregation of neurofilaments and lamellar inclusion bodies in axons were directly related to duration of ketonuria. The data strongly suggest that autonomic neuropathology in the plexuses of Auerbach may be a critical factor underlying gastrointestinal dysfunction in the ketonuric diabetic Chinese hamster.
酮尿性糖尿病中国仓鼠的钡餐X线造影表现为胃、小肠和大肠明显扩张。小肠和大肠内钡剂絮凝表明胃肠蠕动减弱。胃排空时间延长（糖尿病组平均570分钟，对照组200分钟）、粪便形成延迟（糖尿病组平均230分钟，对照组100分钟）和通过时间延迟（糖尿病组平均457分钟，对照组210分钟）进一步表明转运时间受损。小肠奥尔巴赫肌间神经丛的超微结构分析显示，某些远端无髓轴突出现急性变性。观察到肿胀、糖原沉积、神经丝聚集和板层小体密集堆积。钡剂絮凝、糖原沉积、神经丝聚集和轴突内板层包涵体的严重程度和频率与酮尿持续时间直接相关。数据强烈表明，奥尔巴赫神经丛中的自主神经病理学可能是酮尿性糖尿病中国仓鼠胃肠功能障碍的关键因素。
