Diani A R, Davis D E, Fix J D, Swartzman J, Gerritsen G C
Acta Neuropathol. 1981;53(4):293-8. doi: 10.1007/BF00690371.
Fibers from the infradiaphragmatic portion of the sympathetic trunk of ketonuric diabetic Chinese hamsters were quantitatively analyzed by light and electron microscopy to determine frequency distribution and numerical density. Myelinated and unmyelinated fibers displayed a significant reduction in diameter which was exacerbated by increased duration of ketonuria. Mean numerical density of myelinated fibers was reduced whereas that of unmyelinated fibers was increased. The alterations in sympathetic nerve populations are believed to be a manifestation of previously observed demyelination and axonal degeneration. On the basis of axon diameter, it appeared that both visceral afferent and efferent fibers were affected. These data strongly suggest that autonomic neuropathology in the sympathetic trunk of the diabetic Chinese hamster may be a critical factor underlying gastrointestinal dysfunction.
对酮尿症糖尿病中国仓鼠交感干膈下部分的纤维进行了光镜和电镜定量分析，以确定频率分布和数值密度。有髓和无髓纤维的直径均显著减小，酮尿持续时间延长会加剧这种减小。有髓纤维的平均数值密度降低，而无髓纤维的平均数值密度增加。交感神经群体的这些改变被认为是先前观察到的脱髓鞘和轴突退变的表现。根据轴突直径，似乎内脏传入和传出纤维均受到影响。这些数据有力地表明，糖尿病中国仓鼠交感干中的自主神经病理可能是胃肠功能障碍的一个关键因素。
