氯雷他定与胺碘酮联用导致尖端扭转型室速和QT间期延长。
Torsades de pointes and QT prolongation due to a combination of loratadine and amiodarone.
作者信息
Atar Shaul, Freedberg Nahum A, Antonelli Dante, Rosenfeld Tiberio
机构信息
Department of Cardiology, Ha'Emek Medical Center, Afula 18101, Israel.
出版信息
Pacing Clin Electrophysiol. 2003 Mar;26(3):785-6. doi: 10.1046/j.1460-9592.2003.00137.x.
Abstract
Torsades de pointes (TdP) has not been previously reported with loratadine. A 73-year old woman on chronic treatment with amiodarone for atrial fibrillation received loratadine and presented with syncope and multiple episodes of TdP. We suggest that QT interval should be monitored whenever loratadine is co-administered with drugs that may potentially prolong QT.
摘要
此前尚未有关于氯雷他定引发尖端扭转型室速（TdP）的报道。一名73岁长期服用胺碘酮治疗房颤的女性患者在服用氯雷他定后出现晕厥及多次尖端扭转型室速发作。我们建议，当氯雷他定与可能延长QT间期的药物合用时，应监测QT间期。
Zotero 插件