Fatima Nabeela, Mandava Kiranmai, Khatoon Fatima, Badar Juveria, Begum Syeda Fatima, Narasimhan C, Daljeet K, Mohammed Walli
Department of Pharmacy Practice, St Pauls College of Pharmacy, Turkayamjal, India.
Senior Cardiologist and Electrophysiologist, AIG Hospital, Hyderabad, India.
Ann Med Surg (Lond). 2022 Jul 16;80:104167. doi: 10.1016/j.amsu.2022.104167. eCollection 2022 Aug.
Amiodarone belongs to Class-III anti-arrhythmic drugs. It is one of the most effective anti-arrhythmic drugs used to treat or prevent several types of arrhythmias including atrial fibrillation, atrial flutter, ventricular tachycardia, and wide complex tachycardia, but unfortunately carries a high toxicity profile. Also, side effects of amiodarone involving various organs can be life-threatening.
MATERIALS & METHODS: This was an observational study carried out for six months i.e from April to September. The study included patients who are on amiodarone for greater than or equal to six months. The required data was collected in-person from the case sheets, treatment charts, and by interviewing the patients. The data for 67 patients was documented in suitable data collection form for analysis.
From our study data, it was noted that amiodarone was used for 3 different indications-atrial fibrillation, atrial flutter, and ventricular tachycardia. Among 67 patients enrolled, 38 had no side-effects. Side-effects data in the rest grouped basing on the organ system affected: 9 patients had renal effects, 6 patients had ophthalmic effects, 4 patients had endocrine effects, and 5 patients had hepatic effects.
From our study, it is concluded that amiodarone is a safe and effective anti-arrhythmic drug at lower doses i.e. 200-1100 mg/week. When treated in lower doses of 1400-2800 mg/week, many side effects have been incident. Although these effects are mild and develop only after prolonged usage of the drug, it should be used judiciously.
胺碘酮属于Ⅲ类抗心律失常药物。它是用于治疗或预防多种心律失常（包括心房颤动、心房扑动、室性心动过速和宽QRS波心动过速）的最有效抗心律失常药物之一，但不幸的是，其毒性较高。此外，胺碘酮累及多个器官的副作用可能危及生命。
这是一项为期6个月（即从4月至9月）的观察性研究。该研究纳入了服用胺碘酮≥6个月的患者。所需数据通过亲自查阅病历、治疗图表以及与患者面谈来收集。将67例患者的数据记录在合适的数据收集表中以供分析。
从我们的研究数据中可以看出，胺碘酮用于3种不同适应证——心房颤动、心房扑动和室性心动过速。在纳入的67例患者中，38例无副作用。其余患者的副作用数据根据受影响的器官系统进行分组：9例有肾脏方面的影响，6例有眼部方面的影响，4例有内分泌方面的影响，5例有肝脏方面的影响。
从我们的研究得出结论，胺碘酮在较低剂量（即200 - 1100毫克/周）时是一种安全有效的抗心律失常药物。当以1400 - 2800毫克/周的较高剂量治疗时，会出现许多副作用。尽管这些副作用较轻且仅在长期用药后才出现，但仍应谨慎使用。
