Charlesworth B
Genetics. 1976 May;83(1):181-95. doi: 10.1093/genetics/83.1.181.
This paper examines the theory of the evolution of increased recombination between two loci subjected to interactive selection in a temporally fluctuating environment. Both cyclical and stochastic environments are considered. It is shown that temporal variation in the linkage disequilibrium coefficient for the pair of selected loci, due to fluctuations in the selective values of the genotypes at these loci, can give rise to selection in favor of modifier genes increasing recombination. The equilibrium level of recombination established in a given population depends on several factors; it is highest for intermediate values of the environmental periodicity or autocorrelation, for cases when the modifier genes are themselves linked to the selected loci, and for high levels of environmental variation. In general, it seems that the rate of modification of recombination values by this process will be low except when the modifiers are tightly linked to the selected loci. The possible evolutionary significance of this process is discussed in relation to observations on genetic systems of plants and animals.
本文研究了在时间波动环境中，两个受到互作选择的基因座之间重组增加的进化理论。同时考虑了周期性和随机性环境。研究表明，由于这些基因座上基因型选择值的波动，所选基因座对的连锁不平衡系数的时间变化会导致有利于增加重组的修饰基因的选择。给定种群中建立的重组平衡水平取决于几个因素；在环境周期性或自相关的中间值、修饰基因本身与所选基因座连锁的情况以及高水平的环境变异下，重组平衡水平最高。一般来说，除了修饰基因与所选基因座紧密连锁的情况外，这个过程对重组值的修饰速率似乎会很低。本文结合对植物和动物遗传系统的观察，讨论了这一过程可能的进化意义。
