基因连锁对种群平均适合度的影响。
The effect of genetic linkage on the mean fitness of a population.
作者信息
Lewontin R C
出版信息
Proc Natl Acad Sci U S A. 1971 May;68(5):984-6. doi: 10.1073/pnas.68.5.984.
Abstract
If many gene loci are kept in a segregating state by natural selection, the equilibrium frequencies of the genotypes in the population may be a function of the amount of recombination among the genes. It is shown that if the equilibrium vector of gametic frequencies is a continuous function of the set of recombination frequencies among genes, then the mean fitness of the population at equilibrium is a maximum in the absence of recombination. Thus, in general, restriction of recombination increases fitness.
摘要
如果许多基因座通过自然选择保持在分离状态，那么群体中基因型的平衡频率可能是基因间重组量的一个函数。结果表明，如果配子频率的平衡向量是基因间重组频率集合的连续函数，那么在没有重组的情况下，平衡时群体的平均适应度最大。因此，一般来说，重组的限制会增加适应度。
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