Calza L, Manfredi R, Donzelli C, Marinacci G, Colangeli V, Chiodo F
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna, S.Orsola Hospital, Bologna, Italy.
HIV Med. 2003 Apr;4(2):145-8. doi: 10.1046/j.1468-1293.2003.00144.x.
Disseminated histoplasmosis is recognized as a common AIDS-defining opportunistic disease in endemic areas (Americas, Africa, East Asia), while it is rarely described in Europe, usually in individuals returning from endemic regions, or following endogenous reactivation of a latent infection imported long before from overseas countries. However, reports of autochtonous cases in Europe suggest the possible, endemic presence of Histoplasma capsulatum in some European regions, such as the South of France or the Po valley in Italy. A case of disseminated histoplasmosis with atypical, papular and ulcerate skin lesions in an Italian HIV-infected patient, without history of travels outside his native region, is described. Our patient represents the fifth autochtonous case of AIDS-associated histoplasmosis described in Italy.
播散性组织胞浆菌病在流行地区（美洲、非洲、东亚）被认为是一种常见的艾滋病界定机会性疾病，而在欧洲很少被描述，通常发生在从流行地区返回的个体中，或者是在很久以前从海外国家输入的潜伏感染内源性再激活之后。然而，欧洲本土病例的报告表明，荚膜组织胞浆菌可能在一些欧洲地区地方性存在，如法国南部或意大利的波河河谷。本文描述了一例意大利HIV感染患者发生播散性组织胞浆菌病，伴有非典型丘疹和溃疡性皮肤病变，且无其家乡以外旅行史。我们的患者是意大利描述的第五例艾滋病相关组织胞浆菌病本土病例。
