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Porins from Salmonella enterica serovar Typhimurium induce TNF-alpha, IL-6 and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms.
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Campylobacter jejuni cytolethal distending toxin mediates release of interleukin-8 from intestinal epithelial cells.空肠弯曲菌细胞致死性扩张毒素介导白细胞介素-8从肠道上皮细胞的释放。
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空肠弯曲菌对人单核细胞系THP-1促炎反应的诱导作用。

Induction of proinflammatory responses in the human monocytic cell line THP-1 by Campylobacter jejuni.

作者信息

Jones Michael A, Tötemeyer Sabine, Maskell Duncan J, Bryant Clare E, Barrow Paul A

机构信息

Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom.

出版信息

Infect Immun. 2003 May;71(5):2626-33. doi: 10.1128/IAI.71.5.2626-2633.2003.

DOI:10.1128/IAI.71.5.2626-2633.2003
PMID:12704137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC153272/
Abstract

Campylobacter jejuni can cause an enteritis that is associated with an acute inflammatory response at the gut epithelial surface. The signals inducing inflammation are unknown. C. jejuni can penetrate the intestinal epithelial barrier and may then interact with leucocytes, potentially inducing proinflammatory responses. To investigate this, we studied the interaction of C. jejuni with the human monocytic cell line THP-1 and show that a range of proinflammatory cytokines and chemokines is induced. These include interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-6, IL-8, and tumor necrosis factor alpha. Responses can be induced by killed Campylobacter as well as live bacteria and do not depend on the cytolethal distending toxin. C. jejuni infection of THP-1 cells triggers both nuclear translocation of functional NF-kappa B and stimulation of IL-1 alpha, indicating that NF-kappa B-dependent and -independent stimulation is occurring. The extent of proinflammatory cytokine stimulation suggests that monocytes might significantly contribute to intestinal inflammation and disease pathology.

摘要

空肠弯曲菌可引起一种与肠道上皮表面急性炎症反应相关的肠炎。诱导炎症的信号尚不清楚。空肠弯曲菌可穿透肠道上皮屏障，然后可能与白细胞相互作用，潜在地诱导促炎反应。为了对此进行研究，我们研究了空肠弯曲菌与人单核细胞系THP-1的相互作用，并表明可诱导一系列促炎细胞因子和趋化因子。这些包括白细胞介素-1α（IL-1α）、IL-1β、IL-6、IL-8和肿瘤坏死因子α。死的弯曲杆菌以及活细菌均可诱导反应，且不依赖于细胞致死性扩张毒素。THP-1细胞的空肠弯曲菌感染触发了功能性NF-κB的核转位以及IL-1α的刺激，表明正在发生NF-κB依赖性和非依赖性刺激。促炎细胞因子刺激的程度表明单核细胞可能对肠道炎症和疾病病理有显著贡献。