Orwin Paul M, Fitzgerald J Ross, Leung Donald Y M, Gutierrez Juan A, Bohach Gregory A, Schlievert Patrick M
Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Infect Immun. 2003 May;71(5):2916-9. doi: 10.1128/IAI.71.5.2916-2919.2003.
Staphylococcus aureus causes a wide variety of diseases. Major virulence factors of this organism include enterotoxins (SEs) that cause both food poisoning and toxic shock syndrome. Recently, a novel SE, tentatively designated SEL, was identified in a pathogenicity island from a bovine mastitis isolate. The toxin had a molecular weight of 26,000 and an isoelectric point of 8.5. Recombinant SEL shared many biological activities with SEs, including superantigenicity, pyrogenicity, enhancement of endotoxin shock, and lethality in rabbits when administered in subcutaneous miniosmotic pumps, but the protein lacked emetic activity. T cells bearing the T-cell receptor beta chain variable regions 5.1, 5.2, 6.7, 16, and 22 were significantly stimulated by recombinant SEL.
金黄色葡萄球菌可引发多种疾病。该菌的主要毒力因子包括可导致食物中毒和中毒性休克综合征的肠毒素（SEs）。最近，在一株来自牛乳腺炎分离株的致病岛中鉴定出一种新型SE，暂命名为SEL。该毒素分子量为26,000，等电点为8.5。重组SEL与SEs具有许多生物学活性，包括超抗原性、致热性、增强内毒素休克作用以及通过皮下微量渗透泵给药时对兔子的致死性，但该蛋白缺乏催吐活性。携带T细胞受体β链可变区5.1、5.2、6.7、16和22的T细胞受到重组SEL的显著刺激。
