Jacoby R K, Jayson M I
J Rheumatol. 1975 Sep;2(3):270-9.
Adult human articular cartilage was maintained in organ culture for eight days in 20 per cent and 95 per cent oxygen. The higher oxygen tension proved to be lethal to the cartilage, whereas the mean number of surviving chondrocytes in 20 per cent oxygen was 91 per cent of the total. Specimens were cultured with radioactive sulfate (Na235SO4) for two days and the uptake of sulfate (DPM) at 95 per cent oxygen was significantly lower than at 20 per cent oxygen. There was a positive correlation between DPM and uronic acid, and between DPM and DNA (p less than 0.001), but not between DPM and dry weight.
将成人的关节软骨在20%和95%氧气环境下进行器官培养八天。结果证明，较高的氧张力对软骨具有致死性，而在20%氧气环境下存活软骨细胞的平均数量占总数的91%。将样本用放射性硫酸盐（Na235SO4）培养两天，在95%氧气环境下硫酸盐的摄取量（每分钟衰变数）显著低于20%氧气环境下的摄取量。硫酸盐摄取量（每分钟衰变数）与糖醛酸之间、与DNA之间均呈正相关（p<0.001），但与干重之间无相关性。
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