Préziosi Marie-Pierre, Halloran M Elizabeth
Niakhar Project, Institut de Recherche pour le Développement, Dakar, Senegal.
Vaccine. 2003 May 16;21(17-18):1853-61. doi: 10.1016/s0264-410x(03)00007-0.
We estimated the effect of pertussis vaccination on reducing transmission from vaccinated breakthrough cases from a comprehensive follow-up of a community of 30,000 residents in Niakhar, Senegal. Using a wide spectrum of case definitions, vaccine efficacy was estimated as 1 - the ratio of secondary attack rates (SAR) in all households with cases during the calendar year 1993, a pertussis epidemic year. Vaccine efficacy for infectiousness (VEi) was 85% (95% confidence interval (CI), 46-95%) for children vaccinated with three doses of a whole-cell (WC; 94%) or an acellullar (6%) pertussis vaccine, with pertussis defined as a cough >/=21 days with paroxysms confirmed by culture, serology, or contact with a culture-confirmed person. It was high for all case definitions. Partial vaccination reduced infectiousness. Pertussis vaccination is highly effective in reducing transmission from vaccinated breakthrough cases.
我们通过对塞内加尔尼亚喀尔一个拥有30000名居民的社区进行全面随访，评估了百日咳疫苗接种对减少接种疫苗后发生突破性感染病例传播的效果。使用多种病例定义，疫苗效力估计为1减去1993年（百日咳流行年）所有有病例家庭的二代发病率（SAR）之比。对于接种三剂全细胞（WC；94%）或无细胞（6%）百日咳疫苗的儿童，以咳嗽≥21天且伴有经培养、血清学检查确诊的阵发性咳嗽或与培养确诊患者接触来定义百日咳，其传染性疫苗效力（VEi）为85%（95%置信区间（CI），46 - 95%）。对于所有病例定义，该效力都很高。部分接种可降低传染性。百日咳疫苗接种在减少接种疫苗后发生突破性感染病例的传播方面非常有效。
