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瑞典腹膜间皮瘤的时间趋势和职业风险因素

Time trends and occupational risk factors for peritoneal mesothelioma in Sweden.

作者信息

Hemminki Kari, Li Xinjun

机构信息

Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden.

出版信息

J Occup Environ Med. 2003 Apr;45(4):451-5. doi: 10.1097/01.jom.0000052960.59271.d4.

Abstract

Epidemiologic data on peritoneal mesothelioma are scarce but exposure to asbestos is an identified risk factor. To characterize the disease, time trends, age-incidence relationships, and occupational risk factors for peritoneal mesothelioma were studied based on the Swedish Family-Database covering years 1961 to 1998. Peritoneal mesothelioma is a rare disease and only 96 male and 113 female cases were recorded during the 38-year period. Age-standardized incidence of the disease has increased for men until 1985 and leveled off thereafter. The incidence in women has been equally high but it has continued to increase toward the end of the follow-up period. The incidence was maximal at an age around 80 years for both genders. No female occupational or socioeconomic group was at risk. For men, 29% of the cases had typical asbestos related jobs with a SIR of 1.70. Bricklayers and plumbers had the highest risk of 7.22 and 5.12, respectively. Within limits of the sample size, no evidence was noted for risk from environmental exposures to asbestos because the risk of farmers and that of urban residents were not different.

摘要

关于腹膜间皮瘤的流行病学数据稀缺,但已确定接触石棉是一个风险因素。为了描述该疾病的特征,基于涵盖1961年至1998年的瑞典家庭数据库,研究了腹膜间皮瘤的时间趋势、年龄发病率关系和职业风险因素。腹膜间皮瘤是一种罕见疾病,在这38年期间仅记录到96例男性病例和113例女性病例。该疾病的年龄标准化发病率在1985年前男性有所上升,此后趋于平稳。女性的发病率同样较高,但在随访期结束时仍持续上升。男女发病率在80岁左右达到最高。没有女性职业或社会经济群体面临风险。对于男性,29%的病例从事典型的与石棉相关工作,标准化发病比为1.70。瓦工和水管工的风险最高,分别为7.22和5.12。在样本量的限制范围内,未发现环境接触石棉存在风险的证据,因为农民和城市居民的风险并无差异。

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