Wiener P, Burton D, Ajmone-Marsan P, Dunner S, Mommens G, Nijman I J, Rodellar C, Valentini A, Williams J L
Roslin Institute, Edinburgh, Roslin, Midlothian EH25 9PS, UK.
Heredity (Edinb). 2003 May;90(5):350-8. doi: 10.1038/sj.hdy.6800257.
This paper explores patterns of genetic diversity near a locus known to have been under selection. The myostatin gene (GDF-8) has been shown to be associated with double muscling, a phenotype selected for in a number of cattle breeds. We examined population genetic parameters for microsatellite loci at varying distances from GDF-8 in double-muscled (DM) and non-double-muscled (non-DM) cattle breeds in order to assess patterns of diversity. A theoretical analysis was also performed to predict the patterns of diversity expected under different scenarios. We found differences in the patterns of heterozygosity, allele diversity and linkage disequilibrium between DM and non-DM breeds. However, there were some exceptions to the predicted patterns. These are discussed in light of the histories of the breeds and the potential for using microsatellite diversity for mapping trait genes in livestock populations.
本文探讨了已知处于选择作用下的一个基因座附近的遗传多样性模式。肌肉生长抑制素基因（GDF - 8）已被证明与双肌性状有关，双肌性状是在许多牛品种中被选择的一种表型。我们检测了双肌（DM）和非双肌（non - DM）牛品种中与GDF - 8距离不同的微卫星位点的群体遗传参数，以评估多样性模式。还进行了理论分析，以预测不同情况下预期的多样性模式。我们发现DM和non - DM品种在杂合性、等位基因多样性和连锁不平衡模式上存在差异。然而，预测模式也存在一些例外情况。结合品种历史以及利用微卫星多样性在牲畜群体中定位性状基因的可能性对这些情况进行了讨论。
