Charney E, Goodman H C, McBride M, Lyon B, Pratt R
N Engl J Med. 1976 Jul 1;295(1):6-9. doi: 10.1056/NEJM197607012950102.
We investigated whether obese infants tend to become obese adults. Records of subjects born between 1945 and 1955 were reviewed to select three cohorts based on weight in the first six months of age, which exceeded the 90th percentile at least once, ranged between 25th and 75th percentiles or was below 10th percentile at least once. Three hundred and sixty-six subjects, now between 20 and 30 years of age, were located and their present height and weight determined. Thirty-six per cent of those exceeding the 90th percentile as infants were overweight adults, as compared to 14 per cent of the average age and light-weight infants. A significant increase (chi square = 17.2, p less than 0.001) in adult obesity was evident when the infant exceeded the 75th percentile that was independent of his height. Social class, educational level, and parental weight all correlated with adult weight (p less than 0.001). Sex and ordinal position of birth did not. The data suggest that infant weight correlates strongly with adult weight independently of other factors considered.
我们调查了肥胖婴儿是否易于成长为肥胖成年人。回顾了1945年至1955年间出生的受试者记录，根据其在出生后头六个月的体重情况选择了三组队列：至少有一次体重超过第90百分位数、体重处于第25至75百分位数之间或至少有一次体重低于第10百分位数。找到了366名年龄在20至30岁之间的受试者，并测定了他们目前的身高和体重。婴儿期体重超过第90百分位数的受试者中，36%为超重成年人，相比之下，平均年龄组和体重较轻婴儿组的这一比例为14%。当婴儿体重超过第75百分位数且与身高无关时，成人肥胖率显著增加（卡方 = 17.2，p < 0.001）。社会阶层、教育水平和父母体重均与成人体重相关（p < 0.001）。性别和出生顺序则不然。数据表明，婴儿体重与成人体重密切相关，且独立于所考虑的其他因素。
