Jia X, Wang W, Cui W, Han C
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Wei Sheng Yan Jiu. 2000 Jan 30;29(1):54-6.
The present study was designed to investigate the chemopreventive effects of green tea and tea pigments (the main component of black tea) on 1,2-dimethylhydrazine (DMH)-induced rat colorectal carcinogenesis. Compared with the positive control group, green tea and tea pigments groups had less numbers of aberrant crypt foci (ACF) (P < 0.01) at the end of week 16. At the end of week 32, all rats in the positive control group developed colorectal tumors with an average of 2.6 tumors per rat, and a mean volume of 294.7 mm3 per tumor, while in the groups drinking green tea and tea pigments, the average numbers of colorectal tumors per rat were only 47.1% and 43.1% of controls respectively, and the mean tumor volume was inhibited by 77.1% and 68.1% respectively. It was concluded that tea pigments had a chemopreventive effect on colorectal tumor and ACF formation can be used as a useful intermediate end point to study chemopreventive effects on colorectal cancer.
本研究旨在探讨绿茶和茶色素（红茶的主要成分）对1,2 - 二甲基肼（DMH）诱导的大鼠结直肠癌发生的化学预防作用。与阳性对照组相比，在第16周结束时，绿茶组和茶色素组的异常隐窝病灶（ACF）数量较少（P < 0.01）。在第32周结束时，阳性对照组的所有大鼠均发生了结直肠癌，平均每只大鼠有2.6个肿瘤，每个肿瘤的平均体积为294.7立方毫米，而在饮用绿茶和茶色素的组中，每只大鼠的结直肠癌平均数量分别仅为对照组的47.1%和43.1%，平均肿瘤体积分别被抑制了77.1%和68.1%。得出结论，茶色素对结直肠癌具有化学预防作用，ACF形成可作为研究对结直肠癌化学预防作用的有用中间终点。
