Tan K L, Dong F
Specialist Infant-Child Centre, Mt. Elizabeth Medical Centre, Singapore.
Acta Paediatr. 2003;92(3):327-31.
To evaluate the reliability of transcutaneous bilirubinometry (TcB) during and after phototherapy.
TcB was performed on the forehead and chest of infants with neonatal jaundice when capillary blood was sampled for bilirubin determination in a control group of 240 neonates. In a second group of 70 neonates exposed to phototherapy the same procedure was performed after at least 24 h of exposure: on the forehead, TcB was done in the centre of the unexposed area and also on the adjacent exposed area, and the exposed chest. During the post-phototherapy period, TcB was again done during the first and second days, at least 18-24 h after cessation of phototherapy. The results were then statistically evaluated and regression curves were plotted.
A close correlation between TcB values and bilirubin levels was observed in the control group. In the phototherapy group, a correlation was also found between the TcB and the bilirubin values, but this correlation was significantly poorer than that of the controls; the correlation for the covered part of the forehead was significantly better than that of the exposed part but still poorer than that of the controls, though the difference was no longer significant. Skin colour recovered during the post-phototherapy period and correlation was better than that during exposure and no longer significantly different from that of the controls.
Through its bleaching effect on the skin, phototherapy affects the correlation between TcB and the bilirubin values, but does not totally eliminate it. The unexposed parts show a better correlation, though this was still poorer than that of the controls. Recovery of skin colour occurred within 18-24 h after cessation of exposure.
评估光疗期间及光疗后经皮胆红素测定(TcB)的可靠性。
在240例新生儿的对照组中,当采集毛细血管血进行胆红素测定时,对患有新生儿黄疸的婴儿前额和胸部进行经皮胆红素测定。在另一组70例接受光疗的新生儿中,在至少暴露24小时后进行相同操作:在前额,在未暴露区域的中心以及相邻的暴露区域和暴露的胸部进行经皮胆红素测定。在光疗后期间,在光疗停止后至少18 - 24小时的第一天和第二天再次进行经皮胆红素测定。然后对结果进行统计学评估并绘制回归曲线。
在对照组中观察到经皮胆红素测定值与胆红素水平之间密切相关。在光疗组中,经皮胆红素测定值与胆红素值之间也存在相关性,但这种相关性明显低于对照组;前额遮盖部分的相关性明显优于暴露部分,但仍低于对照组,尽管差异不再显著。光疗后期间皮肤颜色恢复,相关性优于光疗期间,且与对照组不再有显著差异。
光疗通过对皮肤的漂白作用,影响经皮胆红素测定值与胆红素值之间的相关性,但并未完全消除这种相关性。未暴露部分显示出较好的相关性,尽管仍低于对照组。暴露停止后18 - 24小时内皮肤颜色恢复。