Hancock John F
Institute for Molecular Bioscience and Department of Molecular and Cellular Pathology, University of Queensland, Brisbane, Australia 4072.
Nat Rev Mol Cell Biol. 2003 May;4(5):373-84. doi: 10.1038/nrm1105.
Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.
传统上认为Ras信号传导仅在相对均匀的质膜内表面发生。最近的研究表明，Ras蛋白与质膜的特定微结构域以及其他细胞内膜动态相互作用。这些不同的膜微环境调节Ras信号输出，并突出了Ras定位与功能之间的复杂相互作用。
