Ras蛋白：来自不同位置的不同信号。

Ras proteins: different signals from different locations.

作者信息

Hancock John F

机构信息

Institute for Molecular Bioscience and Department of Molecular and Cellular Pathology, University of Queensland, Brisbane, Australia 4072.

出版信息

Nat Rev Mol Cell Biol. 2003 May;4(5):373-84. doi: 10.1038/nrm1105.

DOI:10.1038/nrm1105

PMID:12728271

Abstract

Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.

摘要

传统上认为Ras信号传导仅在相对均匀的质膜内表面发生。最近的研究表明，Ras蛋白与质膜的特定微结构域以及其他细胞内膜动态相互作用。这些不同的膜微环境调节Ras信号输出，并突出了Ras定位与功能之间的复杂相互作用。