Cullen Peter J
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.
Curr Opin Cell Biol. 2006 Apr;18(2):157-61. doi: 10.1016/j.ceb.2006.02.012. Epub 2006 Feb 20.
Calcium (Ca(2+)) is a universal regulator of a wide variety of cellular processes. For such control to be achieved, information is encoded within spatial and temporal components of the underlying Ca(2+) signal. One pathway through which Ca(2+) signals are decoded is the Ras binary switch. Here I describe some recent advances that have shed light on how cells can decode the spatial and temporal aspects of Ca(2+) signals through the regulation of this important signalling switch.
钙（Ca(2+)）是多种细胞过程的通用调节因子。为实现这种调控，信息编码于潜在钙信号的时空成分之中。钙信号解码的一条途径是Ras二元开关。在此，我描述一些近期进展，这些进展揭示了细胞如何通过对这一重要信号开关的调控来解码钙信号的时空方面。
