Huang Y, Lei L, Gao G, Wang S, Sun X
Department of Pathophysiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China.
Hua Xi Yi Ke Da Xue Xue Bao. 2001 Mar;32(1):9-11.
This study aimed at the biochemical remodeling of myocardial collagen and its relation to cardiac renin-angiotensin system (RAS) after myocardial infarction(MI).
The ventricular and plasma angiotensin II (Ang II) content, total collagen content, and collagen concentration in left ventricle(LV) and right ventricle(RV) of MI and sham-operated control(SOC) rats on 3, 15 and 42 days after operation were measured dynamically by means of radioimmunoassay etc.
The plasma Ang II content increased only in MI rats on day 3. The Ang II content in LV of the MI group increased markedly on day 3 after MI as compared with that of the SOC group. It sustained at this higher level on the 15th and 42th days, and the similar changes were observed in RV as well. The biochemical remodeling of collagen in LV and RV occurred after MI and the remodeling of collagen showed similar patterns with its Ang II content, except that collagen remodeling in RV was delayed than the change of Ang II content.
The cardiac RAS was obviously activated after MI. Ventricular Ang II might play an important role in the biochemical remodeling of myocardial collagen, and its role was independent of circulating RAS.
本研究旨在探讨心肌梗死后心肌胶原的生化重塑及其与心脏肾素-血管紧张素系统（RAS）的关系。
采用放射免疫分析法等动态检测心肌梗死（MI）大鼠及假手术对照（SOC）大鼠术后3天、15天和42天左心室（LV）和右心室（RV）的心室及血浆血管紧张素II（Ang II）含量、总胶原含量和胶原浓度。
仅MI大鼠术后3天血浆Ang II含量升高。MI组LV的Ang II含量在MI后3天较SOC组显著升高。在第15天和第42天维持在较高水平，RV也观察到类似变化。MI后LV和RV均发生胶原生化重塑，且胶原重塑模式与其Ang II含量相似，只是RV的胶原重塑比Ang II含量变化延迟。
MI后心脏RAS明显激活。心室Ang II可能在心肌胶原生化重塑中起重要作用，且其作用独立于循环RAS。
