Cividini Agostino, Cerino Antonella, Muzzi Alba, Furione Milena, Rebucci Chiara, Segagni Laura, Gatti Marta, Barnaba Vincenzo, Mondelli Mario U
Laboratori di Ricerca-Area Infettivologica and Dipartimento di Malattie Infettive, IRCCS Policlinico, San Matteo, and University of Pavia, Italy.
J Clin Microbiol. 2003 May;41(5):2144-6. doi: 10.1128/JCM.41.5.2144-2146.2003.
An immunoassay detecting hepatitis C virus core antigen was evaluated for its ability to predict clinical outcome in a series of patients with acute hepatitis C. In subjects who cleared the virus, core antigen was no longer detectable within 16 weeks of onset, whereas considerable fluctuations were noted among patients progressing to chronic hepatitis, one of whom showed consistently negative values despite the intermittent presence of viral RNA.
对一种检测丙型肝炎病毒核心抗原的免疫测定法进行了评估，以确定其预测一系列急性丙型肝炎患者临床结局的能力。在清除病毒的受试者中，发病后16周内核心抗原不再可检测到，而在进展为慢性肝炎的患者中观察到相当大的波动，其中一名患者尽管病毒RNA间歇性存在，但核心抗原始终呈阴性值。
