Vernadakis Adam J, Koch Horst, Mackinnon Susan E
Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Suite 17424, East Pavilion, Box 8238, One Barnes-Jewish Hospital Plaza, St. Louis, MO 63110, USA.
Clin Plast Surg. 2003 Apr;30(2):247-68, vii. doi: 10.1016/s0094-1298(02)00104-9.
After nerve injury and regeneration, significant pain may be associated with the scar and altered sensation observed within the distribution of the injured nerve. A bulbous swelling may form at the severed nerve end, constituting a traumatic neuroma. The development of a painful neuroma may be more disabling to the patient than an area of anesthesia or even loss of motor function. Effective treatment of the painful neuroma remains a difficult problem. Diminished productivity, alterations in patient lifestyle, and possible progression to chronic pain syndromes must be considered within the scope of neuroma management, and treatment must focus on alleviating the pain and restoring the functional loss caused by the nerve injury. Careful patient selection is the cornerstone of successful outcomes. Once the patient has been selected, the surgical management of the painful neuroma throughout the body is based on basic principles that vary only slightly from region to region. Using these tenets, a neuroma management algorithm has been developed based on the pathophysio-logy of the neuroma, the results of experimental studies, review of patient outcomes, and understanding the psychology of pain in the surgical patient.
神经损伤和再生后,在损伤神经分布区域内观察到的瘢痕和感觉改变可能会伴有明显疼痛。在离断的神经末端可能会形成球样肿胀,构成外伤性神经瘤。疼痛性神经瘤的形成对患者造成的功能障碍可能比麻醉区域甚至运动功能丧失更为严重。疼痛性神经瘤的有效治疗仍然是一个难题。在神经瘤治疗范围内,必须考虑生产力下降、患者生活方式改变以及可能进展为慢性疼痛综合征等问题,治疗必须专注于缓解疼痛并恢复神经损伤导致的功能丧失。仔细选择患者是取得成功治疗效果的基石。一旦选定患者,全身疼痛性神经瘤的手术治疗基于一些基本原则,这些原则在不同区域仅有细微差异。依据这些原则,基于神经瘤的病理生理学、实验研究结果、患者治疗效果回顾以及对手术患者疼痛心理的理解,制定了一种神经瘤治疗算法。