Mehta Komal, Balaraman R, Amin A H, Bafna P A, Gulati O D
Department of Pharmacy, Faculty of Technology and Engineering, The M.S. University of Baroda, Kalabhavan, Gujarat, India.
J Ethnopharmacol. 2003 Jun;86(2-3):191-5. doi: 10.1016/s0378-8741(03)00075-8.
Rabbits were fed Moringa oleifera (200mg/kg/day, p.o.) or lovastatin (6mg/kg/day, p.o.) in banana pulp along with standard laboratory diet and hypercholesterolaemic diet for 120 days. Moringa oleifera and lovastatin were found to lower the serum cholesterol, phospholipid, triglyceride, VLDL, LDL, cholesterol to phospholipid ratio and atherogenic index, but were found to increase the HDL ratio (HDL/HDL-total cholesterol) as compared to the corresponding control groups. Treatment with M. oleifera or lovastatin in normal rabbits decreased the HDL levels. However, HDL levels were significantly increased or decreased in M. oleifera- or lovastatin-treated hypercholesterolaemic rabbits, respectively. Lovastatin- or M. oleifera-treated hypercholesterolaemic rabbits showed decrease in lipid profile of liver, heart and aorta while similar treatment of normal animals did not produce significant reduction in heart. Moringa oleifera was found to increase the excretion of faecal cholesterol. Thus, the study demonstrates that M. oleifera possesses a hypolipidaemic effect.
将兔子分为几组，分别喂食添加了辣木（200毫克/千克/天，口服）或洛伐他汀（6毫克/千克/天，口服）的香蕉果肉，同时搭配标准实验室饮食和高胆固醇饮食，持续120天。结果发现，与相应的对照组相比，辣木和洛伐他汀均可降低血清胆固醇、磷脂、甘油三酯、极低密度脂蛋白、低密度脂蛋白、胆固醇与磷脂的比值以及动脉粥样硬化指数，但会提高高密度脂蛋白比值（高密度脂蛋白/总胆固醇）。在正常兔子中，用辣木或洛伐他汀治疗会降低高密度脂蛋白水平。然而，在辣木或洛伐他汀治疗的高胆固醇血症兔子中，高密度脂蛋白水平分别显著升高或降低。洛伐他汀或辣木治疗的高胆固醇血症兔子的肝脏、心脏和主动脉脂质水平降低，而对正常动物进行类似治疗时，心脏脂质水平没有显著降低。研究发现，辣木可增加粪便胆固醇的排泄。因此，该研究表明辣木具有降血脂作用。
