Helmy Shahinaz A, Morsy Nashwa F S, Elaby Shahenda M, Ghaly Mohammed A A
1 Department of Food Science, Faculty of Agriculture, Cairo University , Giza, Egypt .
2 Regional Center for Food and Feed, Agriculture Research Center , Giza, Egypt .
J Med Food. 2017 Aug;20(8):755-762. doi: 10.1089/jmf.2016.0155. Epub 2017 May 1.
The leaves of Moringa oleifera Lam possess some potential medicinal value. The aim of this study was to evaluate the protective effect of M. oleifera leaf powder and its extract against hyperlipidemia in rats. Adult male albino rats were divided into six groups. The first group was fed on a basal diet that served as a negative control, whereas the others were fed on a high-fat diet (HFD) containing moringa leaf powder at 0.737% or 1.475% or administered daily with 200 or 400 mg dry moringa leaf extract/kg bw for 60 days. A positive control group was fed on the HFD. Serum indices related to lipid profile, oxidative status, and liver function were analyzed. Feeding rats on an HFD containing moringa leaf powder at 0.737% or an oral dose of its dry extract at 400 mg/kg bw alleviated the harmful elevation of cholesterol, triglycerides, low-density lipoprotein cholesterol, malondialdehyde, and the activities of alanine aminotransferase and aspartate aminotransferase in serum that were induced by the HFD. This is the first study demonstrating the hypocholesterolemic effect of M. oleifera leaf powder.
辣木的叶子具有一定的潜在药用价值。本研究的目的是评估辣木叶粉及其提取物对大鼠高脂血症的保护作用。成年雄性白化大鼠被分为六组。第一组喂食基础饮食作为阴性对照，而其他组则喂食含有0.737%或1.475%辣木叶粉的高脂饮食（HFD），或每天给予200或400毫克干辣木叶提取物/千克体重，持续60天。一个阳性对照组喂食高脂饮食。分析了与血脂谱、氧化状态和肝功能相关的血清指标。给大鼠喂食含有0.737%辣木叶粉的高脂饮食或口服400毫克/千克体重的干提取物，可减轻高脂饮食诱导的血清中胆固醇、甘油三酯、低密度脂蛋白胆固醇、丙二醛以及丙氨酸转氨酶和天冬氨酸转氨酶活性的有害升高。这是第一项证明辣木叶粉具有降胆固醇作用的研究。
